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Infection of armadillos with Mycobacterium leprae. Ultrastructural studies of peripheral nerve.
Arch Pathol Lab Med. 1976 Apr; 100(4):175-81.AP

Abstract

Peripheral nerves of armadillos were studied 16 to 30 months after intradermal or intravenous inoculation with Mycobacterium leprae. Numerous bacilli were found within macrophages, Schwann cells, and perineurial cells; endothelial cells, pericytes and fibroblasts were involved as well. The bacilli were characteristically contained in membrane-limited vacuoles that were interpreted as being phagosomes. Some of the phagosomes contained granular, membranous, and vesicular debris considered to be bacillary degradation products, suggesting that lysosomal activity was present within the phagosomes. Multivesicular bodies, a few of which contained bacilli, were abundant in macrophages and perineurial cells. An unusual proliferation of irregular tubulovesicular profiles was noted, especially in Schwann and perineurial cell cytoplasm, surrounding and within phagosomes containing bacilli. The pattern of cellular involvement of neural structures with M leprae was similar to that observed in lepromatous leprous neuritis in humans.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

786213

Citation

Balentine, J D., et al. "Infection of Armadillos With Mycobacterium Leprae. Ultrastructural Studies of Peripheral Nerve." Archives of Pathology & Laboratory Medicine, vol. 100, no. 4, 1976, pp. 175-81.
Balentine JD, Chang SC, Issar SL. Infection of armadillos with Mycobacterium leprae. Ultrastructural studies of peripheral nerve. Arch Pathol Lab Med. 1976;100(4):175-81.
Balentine, J. D., Chang, S. C., & Issar, S. L. (1976). Infection of armadillos with Mycobacterium leprae. Ultrastructural studies of peripheral nerve. Archives of Pathology & Laboratory Medicine, 100(4), 175-81.
Balentine JD, Chang SC, Issar SL. Infection of Armadillos With Mycobacterium Leprae. Ultrastructural Studies of Peripheral Nerve. Arch Pathol Lab Med. 1976;100(4):175-81. PubMed PMID: 786213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infection of armadillos with Mycobacterium leprae. Ultrastructural studies of peripheral nerve. AU - Balentine,J D, AU - Chang,S C, AU - Issar,S L, PY - 1976/4/1/pubmed PY - 1976/4/1/medline PY - 1976/4/1/entrez SP - 175 EP - 81 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 100 IS - 4 N2 - Peripheral nerves of armadillos were studied 16 to 30 months after intradermal or intravenous inoculation with Mycobacterium leprae. Numerous bacilli were found within macrophages, Schwann cells, and perineurial cells; endothelial cells, pericytes and fibroblasts were involved as well. The bacilli were characteristically contained in membrane-limited vacuoles that were interpreted as being phagosomes. Some of the phagosomes contained granular, membranous, and vesicular debris considered to be bacillary degradation products, suggesting that lysosomal activity was present within the phagosomes. Multivesicular bodies, a few of which contained bacilli, were abundant in macrophages and perineurial cells. An unusual proliferation of irregular tubulovesicular profiles was noted, especially in Schwann and perineurial cell cytoplasm, surrounding and within phagosomes containing bacilli. The pattern of cellular involvement of neural structures with M leprae was similar to that observed in lepromatous leprous neuritis in humans. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/786213/Infection_of_armadillos_with_Mycobacterium_leprae__Ultrastructural_studies_of_peripheral_nerve_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -