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Baseline serum and cerebrospinal fluid magnesium levels in normal pregnancy and preeclampsia.
Obstet Gynecol. 1995 Mar; 85(3):444-8.OG

Abstract

OBJECTIVE

To determine whether baseline cerebrospinal fluid magnesium levels in preeclampsia differ from those in normal pregnancy, and to ascertain whether pre-treatment cerebrospinal fluid magnesium levels correlate with serum levels, which would suggest a baseline alteration in the blood-brain barrier in preeclampsia.

METHODS

When spinal analgesia or anesthesia was administered for delivery, serum and cerebrospinal fluid magnesium levels were determined in 20 normal gravidas and 20 preeclamptic women not treated with magnesium sulfate. Data were analyzed by two-sided Student t test and regression analysis.

RESULTS

Mean (+/- standard deviation) cerebrospinal fluid magnesium level for preeclamptic patients was 2.23 +/- 0.09 mEq/L, which was not significantly different from controls. Regression analysis revealed no significant correlation between cerebrospinal fluid and serum magnesium levels for either normal or preeclamptic gravidas.

CONCLUSION

During the third trimester, there is no difference in baseline, pre-treatment cerebrospinal fluid magnesium levels in preeclamptic patients compared to normal subjects, and no correlation between cerebrospinal fluid and serum magnesium over the range of baseline values.

Authors+Show Affiliations

Department of Anesthesiology, New York Hospital, Cornell Medical Center, New York.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7862389

Citation

Fong, J, et al. "Baseline Serum and Cerebrospinal Fluid Magnesium Levels in Normal Pregnancy and Preeclampsia." Obstetrics and Gynecology, vol. 85, no. 3, 1995, pp. 444-8.
Fong J, Gurewitsch ED, Volpe L, et al. Baseline serum and cerebrospinal fluid magnesium levels in normal pregnancy and preeclampsia. Obstet Gynecol. 1995;85(3):444-8.
Fong, J., Gurewitsch, E. D., Volpe, L., Wagner, W. E., Gomillion, M. C., & August, P. (1995). Baseline serum and cerebrospinal fluid magnesium levels in normal pregnancy and preeclampsia. Obstetrics and Gynecology, 85(3), 444-8.
Fong J, et al. Baseline Serum and Cerebrospinal Fluid Magnesium Levels in Normal Pregnancy and Preeclampsia. Obstet Gynecol. 1995;85(3):444-8. PubMed PMID: 7862389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baseline serum and cerebrospinal fluid magnesium levels in normal pregnancy and preeclampsia. AU - Fong,J, AU - Gurewitsch,E D, AU - Volpe,L, AU - Wagner,W E, AU - Gomillion,M C, AU - August,P, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 444 EP - 8 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 85 IS - 3 N2 - OBJECTIVE: To determine whether baseline cerebrospinal fluid magnesium levels in preeclampsia differ from those in normal pregnancy, and to ascertain whether pre-treatment cerebrospinal fluid magnesium levels correlate with serum levels, which would suggest a baseline alteration in the blood-brain barrier in preeclampsia. METHODS: When spinal analgesia or anesthesia was administered for delivery, serum and cerebrospinal fluid magnesium levels were determined in 20 normal gravidas and 20 preeclamptic women not treated with magnesium sulfate. Data were analyzed by two-sided Student t test and regression analysis. RESULTS: Mean (+/- standard deviation) cerebrospinal fluid magnesium level for preeclamptic patients was 2.23 +/- 0.09 mEq/L, which was not significantly different from controls. Regression analysis revealed no significant correlation between cerebrospinal fluid and serum magnesium levels for either normal or preeclamptic gravidas. CONCLUSION: During the third trimester, there is no difference in baseline, pre-treatment cerebrospinal fluid magnesium levels in preeclamptic patients compared to normal subjects, and no correlation between cerebrospinal fluid and serum magnesium over the range of baseline values. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/7862389/Baseline_serum_and_cerebrospinal_fluid_magnesium_levels_in_normal_pregnancy_and_preeclampsia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0029-7844(94)00413-8 DB - PRIME DP - Unbound Medicine ER -