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Adjunctive fluoxetine in the treatment of negative symptoms in chronic schizophrenic patients.
Int Clin Psychopharmacol 1994; 9(4):281-5IC

Abstract

The effect of adjunctive fluoxetine on negative schizophrenic symptoms was evaluated in 34 chronic schizophrenic in-patients on maintenance therapy with neuroleptics. They received randomly, on a double-blind basis, fluoxetine (20 mg/day) or placebo for 12 weeks. In the fluoxetine group, three patients dropped out because of side effects. Negative symptoms, as measured by change on the Scale for Assessment of Negative Symptoms at the end point compared to baseline values, were significantly improved in fluoxetine-treated patients (p < 0.001), but not in the placebo group. Fluoxetine treatment did not influence positive schizophrenic symptoms, while it induced a slight, but statistically significant, decrease (p < 0.05) in depressive symptoms, as measured by the Hamilton Rating Scale for Depression. Unwanted effects were more common among patients receiving fluoxetine. These data suggest that the addition of fluoxetine to neuroleptic treatment may be beneficial in some schizophrenic patients with negative symptoms.

Authors+Show Affiliations

Institute of Pharmacology, University of Messina, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7868850

Citation

Spina, E, et al. "Adjunctive Fluoxetine in the Treatment of Negative Symptoms in Chronic Schizophrenic Patients." International Clinical Psychopharmacology, vol. 9, no. 4, 1994, pp. 281-5.
Spina E, De Domenico P, Ruello C, et al. Adjunctive fluoxetine in the treatment of negative symptoms in chronic schizophrenic patients. Int Clin Psychopharmacol. 1994;9(4):281-5.
Spina, E., De Domenico, P., Ruello, C., Longobardo, N., Gitto, C., Ancione, M., ... Caputi, A. P. (1994). Adjunctive fluoxetine in the treatment of negative symptoms in chronic schizophrenic patients. International Clinical Psychopharmacology, 9(4), pp. 281-5.
Spina E, et al. Adjunctive Fluoxetine in the Treatment of Negative Symptoms in Chronic Schizophrenic Patients. Int Clin Psychopharmacol. 1994;9(4):281-5. PubMed PMID: 7868850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adjunctive fluoxetine in the treatment of negative symptoms in chronic schizophrenic patients. AU - Spina,E, AU - De Domenico,P, AU - Ruello,C, AU - Longobardo,N, AU - Gitto,C, AU - Ancione,M, AU - Di Rosa,A E, AU - Caputi,A P, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 281 EP - 5 JF - International clinical psychopharmacology JO - Int Clin Psychopharmacol VL - 9 IS - 4 N2 - The effect of adjunctive fluoxetine on negative schizophrenic symptoms was evaluated in 34 chronic schizophrenic in-patients on maintenance therapy with neuroleptics. They received randomly, on a double-blind basis, fluoxetine (20 mg/day) or placebo for 12 weeks. In the fluoxetine group, three patients dropped out because of side effects. Negative symptoms, as measured by change on the Scale for Assessment of Negative Symptoms at the end point compared to baseline values, were significantly improved in fluoxetine-treated patients (p < 0.001), but not in the placebo group. Fluoxetine treatment did not influence positive schizophrenic symptoms, while it induced a slight, but statistically significant, decrease (p < 0.05) in depressive symptoms, as measured by the Hamilton Rating Scale for Depression. Unwanted effects were more common among patients receiving fluoxetine. These data suggest that the addition of fluoxetine to neuroleptic treatment may be beneficial in some schizophrenic patients with negative symptoms. SN - 0268-1315 UR - https://www.unboundmedicine.com/medline/citation/7868850/Adjunctive_fluoxetine_in_the_treatment_of_negative_symptoms_in_chronic_schizophrenic_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=7868850.ui DB - PRIME DP - Unbound Medicine ER -