Tags

Type your tag names separated by a space and hit enter

Genetic control of susceptibility to leprosy in French Polynesia; no evidence for linkage with markers on telomeric human chromosome 2.
Int J Lepr Other Mycobact Dis. 1994 Dec; 62(4):499-511.IJ

Abstract

Several lines of evidence have suggested a role of genetic factors in susceptibility to leprosy. In the mouse, natural susceptibility to infection with mycobacteria is controlled by the chromosome 1 Bcg locus, a region which is syntenic with a fragment of the human chromosome 2q, region q31-q37. It has been postulated that a human homolog of the Bcg gene controls susceptibility to leprosy per se, and may be located on chromosome 2q. In order to test the influence of this putative gene on leprosy per se, we performed linkage analyses in a set of seven multicase French Polynesian pedigrees, using an affected sib pair method and the LOD score method employing different modes of inheritance. Family members were typed for eight polymorphic loci on chromosome 2q: CRYGP1, FN, TNP1, VIL, DES, INH, PAX3, and UGT1A1. Our data provide evidence against the presence of a gene controlling susceptibility to leprosy per se on human chromosome 2q in the French Polynesian population.

Authors+Show Affiliations

Institut Territorial de Recherches Medicales Louis Malarde, Papeete, Tahiti, French Polynesia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7868946

Citation

Levee, G, et al. "Genetic Control of Susceptibility to Leprosy in French Polynesia; No Evidence for Linkage With Markers On Telomeric Human Chromosome 2." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 62, no. 4, 1994, pp. 499-511.
Levee G, Liu J, Gicquel B, et al. Genetic control of susceptibility to leprosy in French Polynesia; no evidence for linkage with markers on telomeric human chromosome 2. Int J Lepr Other Mycobact Dis. 1994;62(4):499-511.
Levee, G., Liu, J., Gicquel, B., Chanteau, S., & Schurr, E. (1994). Genetic control of susceptibility to leprosy in French Polynesia; no evidence for linkage with markers on telomeric human chromosome 2. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 62(4), 499-511.
Levee G, et al. Genetic Control of Susceptibility to Leprosy in French Polynesia; No Evidence for Linkage With Markers On Telomeric Human Chromosome 2. Int J Lepr Other Mycobact Dis. 1994;62(4):499-511. PubMed PMID: 7868946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic control of susceptibility to leprosy in French Polynesia; no evidence for linkage with markers on telomeric human chromosome 2. AU - Levee,G, AU - Liu,J, AU - Gicquel,B, AU - Chanteau,S, AU - Schurr,E, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 499 EP - 511 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int. J. Lepr. Other Mycobact. Dis. VL - 62 IS - 4 N2 - Several lines of evidence have suggested a role of genetic factors in susceptibility to leprosy. In the mouse, natural susceptibility to infection with mycobacteria is controlled by the chromosome 1 Bcg locus, a region which is syntenic with a fragment of the human chromosome 2q, region q31-q37. It has been postulated that a human homolog of the Bcg gene controls susceptibility to leprosy per se, and may be located on chromosome 2q. In order to test the influence of this putative gene on leprosy per se, we performed linkage analyses in a set of seven multicase French Polynesian pedigrees, using an affected sib pair method and the LOD score method employing different modes of inheritance. Family members were typed for eight polymorphic loci on chromosome 2q: CRYGP1, FN, TNP1, VIL, DES, INH, PAX3, and UGT1A1. Our data provide evidence against the presence of a gene controlling susceptibility to leprosy per se on human chromosome 2q in the French Polynesian population. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/7868946/Genetic_control_of_susceptibility_to_leprosy_in_French_Polynesia L2 - http://www.diseaseinfosearch.org/result/8732 DB - PRIME DP - Unbound Medicine ER -