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Effect of acute and chronic diisopropylfluorophosphate and atropine administration on somatostatin binding in the rat frontoparietal cortex and hippocampus.
Psychopharmacology (Berl). 1993; 110(1-2):103-9.P

Abstract

The acute and chronic administration of diisopropylfluorophosphate (DFP), an inhibitor of acetylcholinesterase (AChE), and of atropine, a blocker of muscarinic cholinergic receptors, did not affect somatostatin-like immunoreactivity (SLI) content in the frontoparietal cortex and hippocampus of rats. Acute and chronic DFP administration increased the number of specific 125I-Tyr11-somatostatin (125I-Tyr11-SS) receptors in synaptosomes from the frontoparietal cortex but not in those from the hippocampus and did not change the affinity constant. This increase in 125I-Tyr11-SS binding was not due to a direct effect of DFP on somatostatin (SS) receptors since no rise of binding was produced by high concentrations of DFP (10(-5) M) when added in vitro. The increase could be blocked by pretreatment with atropine. The acute administration of atropine alone had no observable effect on the number of SS receptors. However, repeated atropine administration produced a significant decrease in the 125I-Tyr11-SS binding in synaptosomes from the frontoparietal cortex but not in those from the hippocampus although the affinity constant was unchanged. The results suggest that interactions between somatostatinergic and cholinergic receptors may be important in the rat frontoparietal cortex.

Authors+Show Affiliations

Alonso IA
Department of Biochemistry and Molecular Biology, Medical School, University of Alcala, Madrid, Spain.
Prieto JC
No affiliation info available
Arilla E
No affiliation info available

MeSH

AnimalsAtropineFrontal LobeHippocampusIn Vitro TechniquesIsoflurophateParietal LobeRatsRats, WistarReceptors, SomatostatinSomatostatinSynaptosomes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7870867

Citation

Alonso, I A., et al. "Effect of Acute and Chronic Diisopropylfluorophosphate and Atropine Administration On Somatostatin Binding in the Rat Frontoparietal Cortex and Hippocampus." Psychopharmacology, vol. 110, no. 1-2, 1993, pp. 103-9.
Alonso IA, Prieto JC, Arilla E. Effect of acute and chronic diisopropylfluorophosphate and atropine administration on somatostatin binding in the rat frontoparietal cortex and hippocampus. Psychopharmacology (Berl). 1993;110(1-2):103-9.
Alonso, I. A., Prieto, J. C., & Arilla, E. (1993). Effect of acute and chronic diisopropylfluorophosphate and atropine administration on somatostatin binding in the rat frontoparietal cortex and hippocampus. Psychopharmacology, 110(1-2), 103-9.
Alonso IA, Prieto JC, Arilla E. Effect of Acute and Chronic Diisopropylfluorophosphate and Atropine Administration On Somatostatin Binding in the Rat Frontoparietal Cortex and Hippocampus. Psychopharmacology (Berl). 1993;110(1-2):103-9. PubMed PMID: 7870867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of acute and chronic diisopropylfluorophosphate and atropine administration on somatostatin binding in the rat frontoparietal cortex and hippocampus. AU - Alonso,I A, AU - Prieto,J C, AU - Arilla,E, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 103 EP - 9 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 110 IS - 1-2 N2 - The acute and chronic administration of diisopropylfluorophosphate (DFP), an inhibitor of acetylcholinesterase (AChE), and of atropine, a blocker of muscarinic cholinergic receptors, did not affect somatostatin-like immunoreactivity (SLI) content in the frontoparietal cortex and hippocampus of rats. Acute and chronic DFP administration increased the number of specific 125I-Tyr11-somatostatin (125I-Tyr11-SS) receptors in synaptosomes from the frontoparietal cortex but not in those from the hippocampus and did not change the affinity constant. This increase in 125I-Tyr11-SS binding was not due to a direct effect of DFP on somatostatin (SS) receptors since no rise of binding was produced by high concentrations of DFP (10(-5) M) when added in vitro. The increase could be blocked by pretreatment with atropine. The acute administration of atropine alone had no observable effect on the number of SS receptors. However, repeated atropine administration produced a significant decrease in the 125I-Tyr11-SS binding in synaptosomes from the frontoparietal cortex but not in those from the hippocampus although the affinity constant was unchanged. The results suggest that interactions between somatostatinergic and cholinergic receptors may be important in the rat frontoparietal cortex. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/7870867/Effect_of_acute_and_chronic_diisopropylfluorophosphate_and_atropine_administration_on_somatostatin_binding_in_the_rat_frontoparietal_cortex_and_hippocampus_ DB - PRIME DP - Unbound Medicine ER -