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Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice.
Psychopharmacology (Berl). 1993; 111(2):134-8.P

Abstract

Post-training administration of the GABA-A and GABA-B receptor agonists muscimol and baclofen dose-dependently impaired retention of an inhibitory avoidance response in C57 mice, while improving memory consolidation in the DBA strain. By contrast, picrotoxin (blocker of GABA-activated ionophores), bicuculline (GABA-A antagonist) and CGP 35348 (GABA-B antagonist) dose-dependently improved retention in C57 mice and impaired it in DBA mice. These effects cannot be ascribed to non-specific actions of the drugs on retention performance, as the latencies during the retention test of those mice that had not received footshock during the training were not lengthened by the post-training drug administration. The effects on retention performance induced by GABA agonists and antagonists are probably due to an effect on memory consolidation, since they are observed when the drugs are given at short, but not at long, intervals after training. These results are discussed in terms of possible interaction of GABA systems with endogenous opioid and dopamine systems, whose activation has been shown to produce strain-dependent effects on memory processes. The possible utilization of these results for a genetic behavioral approach with recombinant inbred (RI) mice is also considered.

Authors+Show Affiliations

Istituto di Psicobiologia e Psicofarmacologia (C.N.R.), Roma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7870943

Citation

Castellano, C, et al. "Strain-dependent Effects of Post-training GABA Receptor Agonists and Antagonists On Memory Storage in Mice." Psychopharmacology, vol. 111, no. 2, 1993, pp. 134-8.
Castellano C, Cestari V, Cabib S, et al. Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice. Psychopharmacology (Berl). 1993;111(2):134-8.
Castellano, C., Cestari, V., Cabib, S., & Puglisi-Allegra, S. (1993). Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice. Psychopharmacology, 111(2), 134-8.
Castellano C, et al. Strain-dependent Effects of Post-training GABA Receptor Agonists and Antagonists On Memory Storage in Mice. Psychopharmacology (Berl). 1993;111(2):134-8. PubMed PMID: 7870943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice. AU - Castellano,C, AU - Cestari,V, AU - Cabib,S, AU - Puglisi-Allegra,S, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 134 EP - 8 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 111 IS - 2 N2 - Post-training administration of the GABA-A and GABA-B receptor agonists muscimol and baclofen dose-dependently impaired retention of an inhibitory avoidance response in C57 mice, while improving memory consolidation in the DBA strain. By contrast, picrotoxin (blocker of GABA-activated ionophores), bicuculline (GABA-A antagonist) and CGP 35348 (GABA-B antagonist) dose-dependently improved retention in C57 mice and impaired it in DBA mice. These effects cannot be ascribed to non-specific actions of the drugs on retention performance, as the latencies during the retention test of those mice that had not received footshock during the training were not lengthened by the post-training drug administration. The effects on retention performance induced by GABA agonists and antagonists are probably due to an effect on memory consolidation, since they are observed when the drugs are given at short, but not at long, intervals after training. These results are discussed in terms of possible interaction of GABA systems with endogenous opioid and dopamine systems, whose activation has been shown to produce strain-dependent effects on memory processes. The possible utilization of these results for a genetic behavioral approach with recombinant inbred (RI) mice is also considered. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/7870943/Strain_dependent_effects_of_post_training_GABA_receptor_agonists_and_antagonists_on_memory_storage_in_mice_ L2 - https://medlineplus.gov/memory.html DB - PRIME DP - Unbound Medicine ER -