[Holt-Oram syndrome. Review and report of 2 familial cases].Rev Port Cardiol 1994; 13(12):929-32, 893RP
In 1960 Holt and Oram reported a family in which upper extremity malformations were associated with a secundum atrial septal defect. Since then, more than 200 cases have been reported with a wide spectrum of phenotypes. The authors present the cases of one mother and daughter with Holt-Oram Syndrome (SHO).