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the "Ulm Zucker Uhr System" and its consequences.

Abstract

The "Ulm Zucker Uhr System" comprises a microdialysis probe, a biosensor (Glucosensor Unitec Ulm s.c.), a sender transferring telemetrically the glucose concentrations, and a receiving indicator. The "Zucker Uhr" or "Sugar Watch" looks and operates like a normal wrist watch. We now present the functioning pre-prototype of the first portable system, which 1) is continuously measuring in s.c. tissue the Tissue Glucose (T.G.) concentration in the intercellular fluid on-line enzymatically by combining an enzymatic and an electrochemical (amperometric) technique. 2) is transferring in the patient via the "Zucker Uhr" once per minute the actual tissue glucose concentration, i.e. 1,440 values/24 hours or even 2880 values/48 hours, 3) is actually alarming the patient by optical and acoustic means, when the tissue glucose is too high (hyperglycemia) or too low (hypoglycemia), 4) is storing digitally all values and, therefore, permitting the dialogue between doctor and patient as to his diabetes control in view of his 24 h glucose profile, which is visual on a computer screen. The advantage for the patient is on the one hand the elimination of the multiple pricking in the finger tips for providing capillary blood, and on the other hand, permitting the preview of the limitation and perhaps the complete elimination of the microangiopathy of the retina, kidneys and nervous system. The trend of the T.G. decreases is readily recognizable, which indicates immediately the dangerous hypoglycemia. Likewise, over 48 hours, the hyperglycemic periods are transmitted and recorded which are not measured and reflected by the HbA1 and HbA1c conventional measurements.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    Institut für Diabetes Technologie, Universität Ulm, Germany.

    Source

    MeSH

    Biosensing Techniques
    Blood Glucose
    Blood Glucose Self-Monitoring
    Computers
    Diabetes Mellitus
    Electrochemistry
    Glucose Oxidase
    Humans
    Insulin Infusion Systems
    Microdialysis

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    7875644

    Citation

    TY - JOUR T1 - the "Ulm Zucker Uhr System" and its consequences. A1 - Pfeiffer,E F, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 510 EP - 4 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 26 IS - 11 N2 - The "Ulm Zucker Uhr System" comprises a microdialysis probe, a biosensor (Glucosensor Unitec Ulm s.c.), a sender transferring telemetrically the glucose concentrations, and a receiving indicator. The "Zucker Uhr" or "Sugar Watch" looks and operates like a normal wrist watch. We now present the functioning pre-prototype of the first portable system, which 1) is continuously measuring in s.c. tissue the Tissue Glucose (T.G.) concentration in the intercellular fluid on-line enzymatically by combining an enzymatic and an electrochemical (amperometric) technique. 2) is transferring in the patient via the "Zucker Uhr" once per minute the actual tissue glucose concentration, i.e. 1,440 values/24 hours or even 2880 values/48 hours, 3) is actually alarming the patient by optical and acoustic means, when the tissue glucose is too high (hyperglycemia) or too low (hypoglycemia), 4) is storing digitally all values and, therefore, permitting the dialogue between doctor and patient as to his diabetes control in view of his 24 h glucose profile, which is visual on a computer screen. The advantage for the patient is on the one hand the elimination of the multiple pricking in the finger tips for providing capillary blood, and on the other hand, permitting the preview of the limitation and perhaps the complete elimination of the microangiopathy of the retina, kidneys and nervous system. The trend of the T.G. decreases is readily recognizable, which indicates immediately the dangerous hypoglycemia. Likewise, over 48 hours, the hyperglycemic periods are transmitted and recorded which are not measured and reflected by the HbA1 and HbA1c conventional measurements.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/7875644/abstract/the_"Ulm_Zucker_Uhr_System"_and_its_consequences_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1001746 ER -