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Calibration problems of subcutaneous glucosensors when applied "in-situ" in man.
Horm Metab Res 1994; 26(11):523-5HM

Abstract

Continuous glucose monitoring is the conditio sine qua non to achieve total automation in glucose-controlled insulin-delivery. Several types of glucosensors have been designed according to the enzyme-amperometric method to measure the glucose in different human compartments. However, problems such as long-term stability and calibration prevent this technique being put into practice. A feasible method is needed to calibrate the glucosensor and at the same time should be accepted by the patients. To achieve calibration we determined the absolute tissue glucose, as well as the microdialysis recovery in-vivo, in healthy subjects under normal conditions and during a hyperglycaemic clamp by applying a device based on the recirculation of phosphate buffer saline in a microdialysis probe implanted in the s.c. adipose tissue. The first experiments carried out were promising and encouraging, but further investigations are still needed to favour an ideal "before implantation, all in-vitro" method to calibrate a s.c. glucosensor.

Authors+Show Affiliations

Institut für Diabetes-Technologie, Universität Ulm, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7875646

Citation

Sternberg, F, et al. "Calibration Problems of Subcutaneous Glucosensors when Applied "in-situ" in Man." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 26, no. 11, 1994, pp. 523-5.
Sternberg F, Meyerhoff C, Mennel FJ, et al. Calibration problems of subcutaneous glucosensors when applied "in-situ" in man. Horm Metab Res. 1994;26(11):523-5.
Sternberg, F., Meyerhoff, C., Mennel, F. J., Hoss, U., Mayer, H., Bischof, F., & Pfeiffer, E. F. (1994). Calibration problems of subcutaneous glucosensors when applied "in-situ" in man. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 26(11), pp. 523-5.
Sternberg F, et al. Calibration Problems of Subcutaneous Glucosensors when Applied "in-situ" in Man. Horm Metab Res. 1994;26(11):523-5. PubMed PMID: 7875646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calibration problems of subcutaneous glucosensors when applied "in-situ" in man. AU - Sternberg,F, AU - Meyerhoff,C, AU - Mennel,F J, AU - Hoss,U, AU - Mayer,H, AU - Bischof,F, AU - Pfeiffer,E F, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 523 EP - 5 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 26 IS - 11 N2 - Continuous glucose monitoring is the conditio sine qua non to achieve total automation in glucose-controlled insulin-delivery. Several types of glucosensors have been designed according to the enzyme-amperometric method to measure the glucose in different human compartments. However, problems such as long-term stability and calibration prevent this technique being put into practice. A feasible method is needed to calibrate the glucosensor and at the same time should be accepted by the patients. To achieve calibration we determined the absolute tissue glucose, as well as the microdialysis recovery in-vivo, in healthy subjects under normal conditions and during a hyperglycaemic clamp by applying a device based on the recirculation of phosphate buffer saline in a microdialysis probe implanted in the s.c. adipose tissue. The first experiments carried out were promising and encouraging, but further investigations are still needed to favour an ideal "before implantation, all in-vitro" method to calibrate a s.c. glucosensor. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/7875646/abstract/Calibration_problems_of_subcutaneous_glucosensors_when_applied_"in_situ"_in_man_ DB - PRIME DP - Unbound Medicine ER -