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Immunogenicity and feasibility of purified chick embryo cell vaccine.
Indian Pediatr. 1994 Feb; 31(2):133-7.IP

Abstract

Two hundred seventy-one children reported at the WHO Collaborative Centre for Rabies Epidemiology for South-East Asia at National Institute of Communicable Diseases, Delhi, for advice and antirabies antibody assessment after post-exposure prophylaxis with purified chick embryo cell (PCEC) antirabies vaccine from January 1986 to October 1992. Vaccine was very well tolerated by these children and only 7% complained about mild to moderate side reactions like pain, induration, fever or rash. On an average, every year 50-55 children had reported at this Centre after post-exposure vaccination with PCEC vaccine excepting years 1986 and 1987. One hundred and forty-four children underwent complete course of post-exposure prophylaxis, i.e., 5 or 6 doses on day 0, 3, 7, 14, 30 and 90 (optional) of PCEC vaccine were administered, forty-three (43) children received 4 doses on day 0, 7, 14 and 30 (day 3 dose was omitted) and eighty-four (84) children received 2 to 3 doses as the biting animals were alive for 10 days in these cases. Two hundred and twenty-nine children (84.5%) were bitten by dogs and in 10%, the dog was proven rabid by laboratory examination of dog brain. One hundred and forty-nine (55%) had Class III bite. Serological response, i.e., antirabies antibody titre in all these children were satisfactory (> 0.5 IU/ml) with mean titre of 1.98 IU/ml irrespective of doses of PCEC vaccine administered. No vaccine failure was observed in this study.

Authors+Show Affiliations

WHO Collaborative Centre for Rabies Epidemiology for South-East Asia Zoonosis Division, National Institute of Communicable Diseases (NICD), Sham Nath Marg, Delhi.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7875835

Citation

Sehgal, S, et al. "Immunogenicity and Feasibility of Purified Chick Embryo Cell Vaccine." Indian Pediatrics, vol. 31, no. 2, 1994, pp. 133-7.
Sehgal S, Bhardwaj M, Bhattacharya D. Immunogenicity and feasibility of purified chick embryo cell vaccine. Indian Pediatr. 1994;31(2):133-7.
Sehgal, S., Bhardwaj, M., & Bhattacharya, D. (1994). Immunogenicity and feasibility of purified chick embryo cell vaccine. Indian Pediatrics, 31(2), 133-7.
Sehgal S, Bhardwaj M, Bhattacharya D. Immunogenicity and Feasibility of Purified Chick Embryo Cell Vaccine. Indian Pediatr. 1994;31(2):133-7. PubMed PMID: 7875835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity and feasibility of purified chick embryo cell vaccine. AU - Sehgal,S, AU - Bhardwaj,M, AU - Bhattacharya,D, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 133 EP - 7 JF - Indian pediatrics JO - Indian Pediatr VL - 31 IS - 2 N2 - Two hundred seventy-one children reported at the WHO Collaborative Centre for Rabies Epidemiology for South-East Asia at National Institute of Communicable Diseases, Delhi, for advice and antirabies antibody assessment after post-exposure prophylaxis with purified chick embryo cell (PCEC) antirabies vaccine from January 1986 to October 1992. Vaccine was very well tolerated by these children and only 7% complained about mild to moderate side reactions like pain, induration, fever or rash. On an average, every year 50-55 children had reported at this Centre after post-exposure vaccination with PCEC vaccine excepting years 1986 and 1987. One hundred and forty-four children underwent complete course of post-exposure prophylaxis, i.e., 5 or 6 doses on day 0, 3, 7, 14, 30 and 90 (optional) of PCEC vaccine were administered, forty-three (43) children received 4 doses on day 0, 7, 14 and 30 (day 3 dose was omitted) and eighty-four (84) children received 2 to 3 doses as the biting animals were alive for 10 days in these cases. Two hundred and twenty-nine children (84.5%) were bitten by dogs and in 10%, the dog was proven rabid by laboratory examination of dog brain. One hundred and forty-nine (55%) had Class III bite. Serological response, i.e., antirabies antibody titre in all these children were satisfactory (> 0.5 IU/ml) with mean titre of 1.98 IU/ml irrespective of doses of PCEC vaccine administered. No vaccine failure was observed in this study. SN - 0019-6061 UR - https://www.unboundmedicine.com/medline/citation/7875835/Immunogenicity_and_feasibility_of_purified_chick_embryo_cell_vaccine_ L2 - https://medlineplus.gov/rabies.html DB - PRIME DP - Unbound Medicine ER -