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Soybean phytoestrogen intake and cancer risk.
J Nutr 1995; 125(3 Suppl):757S-770SJN

Abstract

Because many Western diseases are hormone-dependent cancers, we have postulated that the Western diet, compared with a vegetarian or semi-vegetarian diet, may alter hormone production, metabolism or action at the cellular level. Recently, our interest has been focused on the cancer-protective role of some hormone-like diphenolic phytoestrogens of dietary origin, the lignans and isoflavonoids. The precursors of the biologically active compounds originate in soybean products (mainly isoflavonoids but also lignans), as well as whole grain cereals, seeds, probably berries and nuts (mainly lignans). The plant lignan and isoflavonoid glycosides are converted by intestinal bacteria to hormone-like compounds with weak estrogenic and antioxidative activity; they have now been shown to influence not only sex hormone metabolism and biological activity but also intracellular enzymes, protein synthesis, growth factor action, malignant cell proliferation, differentiation and angiogenesis, making them strong candidates for a role as natural cancer protective compounds. Epidemiological investigations support this hypothesis, because the highest levels of these compounds are found in countries or regions with low cancer incidence. This report is a review of results that suggest that the diphenolic isoflavonoids and lignans are natural cancer-protective compounds.

Authors+Show Affiliations

Department of Clinical Chemistry, Helsinki University Central Hospital, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

7884562

Citation

Adlercreutz, C H., et al. "Soybean Phytoestrogen Intake and Cancer Risk." The Journal of Nutrition, vol. 125, no. 3 Suppl, 1995, 757S-770S.
Adlercreutz CH, Goldin BR, Gorbach SL, et al. Soybean phytoestrogen intake and cancer risk. J Nutr. 1995;125(3 Suppl):757S-770S.
Adlercreutz, C. H., Goldin, B. R., Gorbach, S. L., Höckerstedt, K. A., Watanabe, S., Hämäläinen, E. K., ... Adlercreutz, T. (1995). Soybean phytoestrogen intake and cancer risk. The Journal of Nutrition, 125(3 Suppl), 757S-770S. doi:10.1093/jn/125.3_Suppl.757S.
Adlercreutz CH, et al. Soybean Phytoestrogen Intake and Cancer Risk. J Nutr. 1995;125(3 Suppl):757S-770S. PubMed PMID: 7884562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soybean phytoestrogen intake and cancer risk. AU - Adlercreutz,C H, AU - Goldin,B R, AU - Gorbach,S L, AU - Höckerstedt,K A, AU - Watanabe,S, AU - Hämäläinen,E K, AU - Markkanen,M H, AU - Mäkelä,T H, AU - Wähälä,K T, AU - Adlercreutz,T, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 757S EP - 770S JF - The Journal of nutrition JO - J. Nutr. VL - 125 IS - 3 Suppl N2 - Because many Western diseases are hormone-dependent cancers, we have postulated that the Western diet, compared with a vegetarian or semi-vegetarian diet, may alter hormone production, metabolism or action at the cellular level. Recently, our interest has been focused on the cancer-protective role of some hormone-like diphenolic phytoestrogens of dietary origin, the lignans and isoflavonoids. The precursors of the biologically active compounds originate in soybean products (mainly isoflavonoids but also lignans), as well as whole grain cereals, seeds, probably berries and nuts (mainly lignans). The plant lignan and isoflavonoid glycosides are converted by intestinal bacteria to hormone-like compounds with weak estrogenic and antioxidative activity; they have now been shown to influence not only sex hormone metabolism and biological activity but also intracellular enzymes, protein synthesis, growth factor action, malignant cell proliferation, differentiation and angiogenesis, making them strong candidates for a role as natural cancer protective compounds. Epidemiological investigations support this hypothesis, because the highest levels of these compounds are found in countries or regions with low cancer incidence. This report is a review of results that suggest that the diphenolic isoflavonoids and lignans are natural cancer-protective compounds. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/7884562/Soybean_phytoestrogen_intake_and_cancer_risk_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/125.3_Suppl.757S DB - PRIME DP - Unbound Medicine ER -