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Relation of abnormal composition of lipoproteins to HbA1c levels in non-insulin dependent diabetes.
Rev Esp Fisiol 1994; 50(3):145-51RE

Abstract

Plasma lipids and VLDL and HDL composition were studied in a control group of 20 non diabetic subjects and in 31 male middle-age patients with non-insulin dependent diabetes treated by oral hypoglycemic agent glibenclamide and a weight maintaining diet. Data for the diabetics were separated based on haemoglobin A1c of less or greater than 7%. VLDL composition abnormalities were more frequent in the diabetic patients with HbA1c of > 7%. VLDL-cholesterol, VLDL-triglycerides and VLDL-phospholipids were high in all diabetics whereas VLDL-apo B increased only in diabetics with HbA1c > 7%. Apo CII and apo CIII levels and also apo CII/apo CIII ratio were also reduced in the diabetic patients with HbA1c levels of more than 7%. Increases in the apo E and apo E/apo C ratio were also seen in the more hyperglycemic diabetics with HbA1c levels > 7%. In contrast apo CII and apo CIII levels and also Apo CII/Apo CIII ratio remained unaltered in diabetic patients with less than 7% HbA1c levels. In these patients increases in the apo E levels were found while the apo E/apo C ratio remained unaltered. All diabetic patients showed increases in HDL-triglycerides and triglyceride/total cholesterol ratio with respect to control. Decreases in HDL-apo AI were also seen in both groups of diabetics, but the HDL-apo AI/HDL-apo AII ratio did not differ from control.

Authors+Show Affiliations

Laboratorio de Técnicas Instrumentales, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7886271

Citation

Sánchez-Cabezudo, M, et al. "Relation of Abnormal Composition of Lipoproteins to HbA1c Levels in Non-insulin Dependent Diabetes." Revista Espanola De Fisiologia, vol. 50, no. 3, 1994, pp. 145-51.
Sánchez-Cabezudo M, Ródenas S, Cuesta C. Relation of abnormal composition of lipoproteins to HbA1c levels in non-insulin dependent diabetes. Rev Esp Fisiol. 1994;50(3):145-51.
Sánchez-Cabezudo, M., Ródenas, S., & Cuesta, C. (1994). Relation of abnormal composition of lipoproteins to HbA1c levels in non-insulin dependent diabetes. Revista Espanola De Fisiologia, 50(3), pp. 145-51.
Sánchez-Cabezudo M, Ródenas S, Cuesta C. Relation of Abnormal Composition of Lipoproteins to HbA1c Levels in Non-insulin Dependent Diabetes. Rev Esp Fisiol. 1994;50(3):145-51. PubMed PMID: 7886271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of abnormal composition of lipoproteins to HbA1c levels in non-insulin dependent diabetes. AU - Sánchez-Cabezudo,M, AU - Ródenas,S, AU - Cuesta,C, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 145 EP - 51 JF - Revista espanola de fisiologia JO - Rev. Esp. Fisiol. VL - 50 IS - 3 N2 - Plasma lipids and VLDL and HDL composition were studied in a control group of 20 non diabetic subjects and in 31 male middle-age patients with non-insulin dependent diabetes treated by oral hypoglycemic agent glibenclamide and a weight maintaining diet. Data for the diabetics were separated based on haemoglobin A1c of less or greater than 7%. VLDL composition abnormalities were more frequent in the diabetic patients with HbA1c of > 7%. VLDL-cholesterol, VLDL-triglycerides and VLDL-phospholipids were high in all diabetics whereas VLDL-apo B increased only in diabetics with HbA1c > 7%. Apo CII and apo CIII levels and also apo CII/apo CIII ratio were also reduced in the diabetic patients with HbA1c levels of more than 7%. Increases in the apo E and apo E/apo C ratio were also seen in the more hyperglycemic diabetics with HbA1c levels > 7%. In contrast apo CII and apo CIII levels and also Apo CII/Apo CIII ratio remained unaltered in diabetic patients with less than 7% HbA1c levels. In these patients increases in the apo E levels were found while the apo E/apo C ratio remained unaltered. All diabetic patients showed increases in HDL-triglycerides and triglyceride/total cholesterol ratio with respect to control. Decreases in HDL-apo AI were also seen in both groups of diabetics, but the HDL-apo AI/HDL-apo AII ratio did not differ from control. SN - 0034-9402 UR - https://www.unboundmedicine.com/medline/citation/7886271/Relation_of_abnormal_composition_of_lipoproteins_to_HbA1c_levels_in_non_insulin_dependent_diabetes_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -