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The impact of alcohol and hypertension on stroke incidence in a general Japanese population. The Hisayama Study.
Stroke 1995; 26(3):368-72S

Abstract

BACKGROUND AND PURPOSE

The relationship between alcohol intake and stroke has been inconsistent in previous studies. We examined the separate and combined effects of drinking habits and hypertension on stroke incidence in a prospective survey of a general Japanese population.

METHODS

A total of 1621 stroke-free Hisayama residents aged 40 years or older were classified by their alcohol intake into nondrinkers, light drinkers (< 34 g of ethanol per day), and heavy drinkers (> or = 34 g of ethanol per day) and followed up prospectively for 26 years from 1961.

RESULTS

During the follow-up period, cerebral infarction developed in 244 subjects and cerebral hemorrhage in 60. For men, the incidence of cerebral hemorrhage increased significantly with rising alcohol consumption. In contrast, the incidence of cerebral infarction was slightly lower in light drinkers than in nondrinkers, while it increased significantly in heavy drinkers compared with light drinkers. Female drinkers had a lower incidence of cerebral infarction but a slightly higher incidence of cerebral hemorrhage than nondrinkers, as did male light drinkers. Among the hypertensive subjects, the age- and sex-adjusted relative risk of cerebral hemorrhage was significantly elevated in heavy drinkers versus abstainers (3.13; 95% confidence interval [CI], 1.08 to 9.10), but the increase was not significant for light drinkers. In contrast, the relative risk did not significantly increase for normotensive light and heavy drinkers. Compared with hypertensive light drinkers, the relative risk of cerebral infarction significantly increased in hypertensive heavy drinkers (1.96; 95% CI, 1.08 to 3.57) but remained unchanged in normotensive heavy drinkers. Significant associations between alcohol intake and stroke were substantially the same even after controlling for other risk factors in multivariate analysis.

CONCLUSIONS

Among hypertensive individuals, heavy alcohol consumption leads to a significant increase in the risk of cerebral hemorrhage, suggesting a synergistic effect of alcohol and hypertension, while light alcohol consumption significantly reduces the risk of cerebral infarction.

Authors+Show Affiliations

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7886708

Citation

Kiyohara, Y, et al. "The Impact of Alcohol and Hypertension On Stroke Incidence in a General Japanese Population. the Hisayama Study." Stroke, vol. 26, no. 3, 1995, pp. 368-72.
Kiyohara Y, Kato I, Iwamoto H, et al. The impact of alcohol and hypertension on stroke incidence in a general Japanese population. The Hisayama Study. Stroke. 1995;26(3):368-72.
Kiyohara, Y., Kato, I., Iwamoto, H., Nakayama, K., & Fujishima, M. (1995). The impact of alcohol and hypertension on stroke incidence in a general Japanese population. The Hisayama Study. Stroke, 26(3), pp. 368-72.
Kiyohara Y, et al. The Impact of Alcohol and Hypertension On Stroke Incidence in a General Japanese Population. the Hisayama Study. Stroke. 1995;26(3):368-72. PubMed PMID: 7886708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of alcohol and hypertension on stroke incidence in a general Japanese population. The Hisayama Study. AU - Kiyohara,Y, AU - Kato,I, AU - Iwamoto,H, AU - Nakayama,K, AU - Fujishima,M, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 368 EP - 72 JF - Stroke JO - Stroke VL - 26 IS - 3 N2 - BACKGROUND AND PURPOSE: The relationship between alcohol intake and stroke has been inconsistent in previous studies. We examined the separate and combined effects of drinking habits and hypertension on stroke incidence in a prospective survey of a general Japanese population. METHODS: A total of 1621 stroke-free Hisayama residents aged 40 years or older were classified by their alcohol intake into nondrinkers, light drinkers (< 34 g of ethanol per day), and heavy drinkers (> or = 34 g of ethanol per day) and followed up prospectively for 26 years from 1961. RESULTS: During the follow-up period, cerebral infarction developed in 244 subjects and cerebral hemorrhage in 60. For men, the incidence of cerebral hemorrhage increased significantly with rising alcohol consumption. In contrast, the incidence of cerebral infarction was slightly lower in light drinkers than in nondrinkers, while it increased significantly in heavy drinkers compared with light drinkers. Female drinkers had a lower incidence of cerebral infarction but a slightly higher incidence of cerebral hemorrhage than nondrinkers, as did male light drinkers. Among the hypertensive subjects, the age- and sex-adjusted relative risk of cerebral hemorrhage was significantly elevated in heavy drinkers versus abstainers (3.13; 95% confidence interval [CI], 1.08 to 9.10), but the increase was not significant for light drinkers. In contrast, the relative risk did not significantly increase for normotensive light and heavy drinkers. Compared with hypertensive light drinkers, the relative risk of cerebral infarction significantly increased in hypertensive heavy drinkers (1.96; 95% CI, 1.08 to 3.57) but remained unchanged in normotensive heavy drinkers. Significant associations between alcohol intake and stroke were substantially the same even after controlling for other risk factors in multivariate analysis. CONCLUSIONS: Among hypertensive individuals, heavy alcohol consumption leads to a significant increase in the risk of cerebral hemorrhage, suggesting a synergistic effect of alcohol and hypertension, while light alcohol consumption significantly reduces the risk of cerebral infarction. SN - 0039-2499 UR - https://www.unboundmedicine.com/medline/citation/7886708/The_impact_of_alcohol_and_hypertension_on_stroke_incidence_in_a_general_Japanese_population__The_Hisayama_Study_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.str.26.3.368?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -