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Insular lesion evokes autonomic effects of stroke in normotensive and hypertensive rats.
Stroke. 1995 Mar; 26(3):459-65.S

Abstract

BACKGROUND AND PURPOSE

Increases in sympathetic activity and frequency of myocardial damage occur after middle cerebral artery occlusion (MCAO) in Wistar rats, while MCAO in the spontaneously hypertensive rat (SHR) decreases sympathoadrenal activity. Autonomic changes have been suggested to result from damage to the insular cortex (IC).

METHODS

A lesion of the IC was made using the excitotoxin D,L-homocysteic acid (DLH; 1 mol/L), in urethane-anesthetized Wistar rats and SHRs. Mean arterial pressure (MAP), heart rate, renal sympathetic nerve discharge (SND), ECG, and plasma catecholamines were measured in 14 SHRs and 14 Wistar male rats after a 500-nL injection of DLH or phosphate-buffered saline (PBS) into the IC.

RESULTS

Histological examination showed that DLH resulted in neuronal damage throughout the IC. DLH injection initially elevated MAP (at approximately 10 minutes after injection) in Wistar rats but not in SHRs. At 4 hours after the DLH injection, there was a secondary, longer-term increase in MAP in the Wistar rats. MAP decreased in the SHRs after IC lesion such that at 6 hours, lesioned SHRs had a MAP that was significantly lower than that of sham-lesioned SHRs. SND initially increased (at 10 minutes) after DLH injection in Wistar rats. In the SHRs, SND decreased significantly from the initial values, by 3 hours after DLH injection. Plasma catecholamine levels were not significantly changed as a result of IC lesion in the Wistar rats or the SHRs. Heart rates increased in all animals, with no differences between groups. There were no changes in the ECG or in the frequency of cardiac myocytolysis in either strain (sham or lesioned animals).

CONCLUSIONS

IC lesion in the SHR and Wistar rat therefore appears to result in autonomic changes similar to that seen after MCAO. Unlike MCAO, however, the autonomic changes do not appear to be sufficient to produce myocardial damage.

Authors+Show Affiliations

Department of Stroke and Aging, John P. Robarts Research Institute, London, Ontario, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7886725

Citation

Butcher, K S., and D F. Cechetto. "Insular Lesion Evokes Autonomic Effects of Stroke in Normotensive and Hypertensive Rats." Stroke, vol. 26, no. 3, 1995, pp. 459-65.
Butcher KS, Cechetto DF. Insular lesion evokes autonomic effects of stroke in normotensive and hypertensive rats. Stroke. 1995;26(3):459-65.
Butcher, K. S., & Cechetto, D. F. (1995). Insular lesion evokes autonomic effects of stroke in normotensive and hypertensive rats. Stroke, 26(3), 459-65.
Butcher KS, Cechetto DF. Insular Lesion Evokes Autonomic Effects of Stroke in Normotensive and Hypertensive Rats. Stroke. 1995;26(3):459-65. PubMed PMID: 7886725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insular lesion evokes autonomic effects of stroke in normotensive and hypertensive rats. AU - Butcher,K S, AU - Cechetto,D F, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 459 EP - 65 JF - Stroke JO - Stroke VL - 26 IS - 3 N2 - BACKGROUND AND PURPOSE: Increases in sympathetic activity and frequency of myocardial damage occur after middle cerebral artery occlusion (MCAO) in Wistar rats, while MCAO in the spontaneously hypertensive rat (SHR) decreases sympathoadrenal activity. Autonomic changes have been suggested to result from damage to the insular cortex (IC). METHODS: A lesion of the IC was made using the excitotoxin D,L-homocysteic acid (DLH; 1 mol/L), in urethane-anesthetized Wistar rats and SHRs. Mean arterial pressure (MAP), heart rate, renal sympathetic nerve discharge (SND), ECG, and plasma catecholamines were measured in 14 SHRs and 14 Wistar male rats after a 500-nL injection of DLH or phosphate-buffered saline (PBS) into the IC. RESULTS: Histological examination showed that DLH resulted in neuronal damage throughout the IC. DLH injection initially elevated MAP (at approximately 10 minutes after injection) in Wistar rats but not in SHRs. At 4 hours after the DLH injection, there was a secondary, longer-term increase in MAP in the Wistar rats. MAP decreased in the SHRs after IC lesion such that at 6 hours, lesioned SHRs had a MAP that was significantly lower than that of sham-lesioned SHRs. SND initially increased (at 10 minutes) after DLH injection in Wistar rats. In the SHRs, SND decreased significantly from the initial values, by 3 hours after DLH injection. Plasma catecholamine levels were not significantly changed as a result of IC lesion in the Wistar rats or the SHRs. Heart rates increased in all animals, with no differences between groups. There were no changes in the ECG or in the frequency of cardiac myocytolysis in either strain (sham or lesioned animals). CONCLUSIONS: IC lesion in the SHR and Wistar rat therefore appears to result in autonomic changes similar to that seen after MCAO. Unlike MCAO, however, the autonomic changes do not appear to be sufficient to produce myocardial damage. SN - 0039-2499 UR - https://www.unboundmedicine.com/medline/citation/7886725/Insular_lesion_evokes_autonomic_effects_of_stroke_in_normotensive_and_hypertensive_rats_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.str.26.3.459?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -