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Prevalence of gastrointestinal symptoms in diabetic patients and non-diabetic subjects.
Z Gastroenterol. 1994 Nov; 32(11):637-41.ZG

Abstract

To determine the frequency of gastrointestinal symptoms in diabetic patients, 190 patients, consecutively referred to the Diabetes Research Institute, reported their gastrointestinal symptoms on a standardized symptom list. One hundred and eighty non-diabetic healthy subjects served as (matched) controls. Finally, 75 patients with Type 1 (insulin-dependent) diabetes mellitus (33 male, 43 female; age 34,1 (18-60) yrs, diabetes duration: 11,1 (0,3-41) yrs) and 68 patients with Type 2 (non-insulin-dependent) diabetes mellitus (31 male, 37 female, age: 61,4 (37-88) yrs, diabetes duration: 10,7 (0,3-40) yrs) were studied and compared with two cohorts of controls of the same size. There were no differences in prevalence of symptoms referrable to the upper and lower GI-tract in type 1 diabetic patients as compared with controls. Among patients with type 2 diabetes the main gastrointestinal complaint was constipation (22,1% vs 10,3%; p < 0.05). Upper gastrointestinal symptoms were also more frequent among Type 2 diabetic subjects (nausea 11,8% vs 2,9%, p < 0.05). There was a tendency for an increased symptom prevalence with higher age in both type 1 and type 2 diabetes. Presence of peripheral neuropathy was associated with a higher symptom prevalence in type 1 diabetes. After stratification, diabetes duration and glycaemic control (HbA1c) did not influence the frequency of symptoms. Thus, gastrointestinal symptoms occur frequently among both diabetic patients and non-diabetic subjects. However, significant differences were found only in type 2 (non-insulin-dependent) diabetes, the commonest symptom being constipation. These findings support the need of a nondiabetic control group in epidemiological studies evaluating symptom prevalence in diabetes mellitus.

Authors+Show Affiliations

Department of Gastroenterology, Heinrich Heine University, Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7886972

Citation

Enck, P, et al. "Prevalence of Gastrointestinal Symptoms in Diabetic Patients and Non-diabetic Subjects." Zeitschrift Fur Gastroenterologie, vol. 32, no. 11, 1994, pp. 637-41.
Enck P, Rathmann W, Spiekermann M, et al. Prevalence of gastrointestinal symptoms in diabetic patients and non-diabetic subjects. Z Gastroenterol. 1994;32(11):637-41.
Enck, P., Rathmann, W., Spiekermann, M., Czerner, D., Tschöpe, D., Ziegler, D., Strohmeyer, G., & Gries, F. A. (1994). Prevalence of gastrointestinal symptoms in diabetic patients and non-diabetic subjects. Zeitschrift Fur Gastroenterologie, 32(11), 637-41.
Enck P, et al. Prevalence of Gastrointestinal Symptoms in Diabetic Patients and Non-diabetic Subjects. Z Gastroenterol. 1994;32(11):637-41. PubMed PMID: 7886972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of gastrointestinal symptoms in diabetic patients and non-diabetic subjects. AU - Enck,P, AU - Rathmann,W, AU - Spiekermann,M, AU - Czerner,D, AU - Tschöpe,D, AU - Ziegler,D, AU - Strohmeyer,G, AU - Gries,F A, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 637 EP - 41 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 32 IS - 11 N2 - To determine the frequency of gastrointestinal symptoms in diabetic patients, 190 patients, consecutively referred to the Diabetes Research Institute, reported their gastrointestinal symptoms on a standardized symptom list. One hundred and eighty non-diabetic healthy subjects served as (matched) controls. Finally, 75 patients with Type 1 (insulin-dependent) diabetes mellitus (33 male, 43 female; age 34,1 (18-60) yrs, diabetes duration: 11,1 (0,3-41) yrs) and 68 patients with Type 2 (non-insulin-dependent) diabetes mellitus (31 male, 37 female, age: 61,4 (37-88) yrs, diabetes duration: 10,7 (0,3-40) yrs) were studied and compared with two cohorts of controls of the same size. There were no differences in prevalence of symptoms referrable to the upper and lower GI-tract in type 1 diabetic patients as compared with controls. Among patients with type 2 diabetes the main gastrointestinal complaint was constipation (22,1% vs 10,3%; p < 0.05). Upper gastrointestinal symptoms were also more frequent among Type 2 diabetic subjects (nausea 11,8% vs 2,9%, p < 0.05). There was a tendency for an increased symptom prevalence with higher age in both type 1 and type 2 diabetes. Presence of peripheral neuropathy was associated with a higher symptom prevalence in type 1 diabetes. After stratification, diabetes duration and glycaemic control (HbA1c) did not influence the frequency of symptoms. Thus, gastrointestinal symptoms occur frequently among both diabetic patients and non-diabetic subjects. However, significant differences were found only in type 2 (non-insulin-dependent) diabetes, the commonest symptom being constipation. These findings support the need of a nondiabetic control group in epidemiological studies evaluating symptom prevalence in diabetes mellitus. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/7886972/Prevalence_of_gastrointestinal_symptoms_in_diabetic_patients_and_non_diabetic_subjects_ L2 - https://medlineplus.gov/diabetestype2.html DB - PRIME DP - Unbound Medicine ER -