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Detection of Epstein-Barr virus and cytomegalovirus genome in white blood cells from patients with juvenile rheumatoid arthritis and childhood systemic lupus erythematosus.
Int Arch Allergy Immunol. 1995 Mar; 106(3):235-40.IA

Abstract

The role of infectious agents in the pathogenesis of autoimmune diseases has long been a matter of debate. This study investigated the possible role of Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) infections in the pathogenesis of autoimmune diseases by an attempt to demonstrate the presence of the viral genome in the leukocyte of 21 juvenile rheumatoid arthritis (JRA) patients, 20 childhood-onset systemic lupus erythematosus (SLE) patients, and 20 age-matched normals, using polymerase chain reaction (PCR) and DNA probes. The results showed: (1) there was no difference in serum IgG anti-EBV antibody titers among three groups; (2) the EBV PCR-positive rates for JRA and SLE patients and normal controls were 5% (1/21), 10 (2/20), and 0% (0/20), respectively; (3) the HCMV PCR-positive rates for JRA and SLE patients and normal controls were 33% (7/21), 25 (5/20), and 10% (2/20), respectively, and (4) the HCMV-positive rate was 25% for JRA patients with steroid treatment and 33% for those without steroid treatment. It is, therefore, concluded that: (1) the data do not support the participation of EBV and HCMV in the pathogenesis of childhood-onset SLE and JRA; (2) steroid therapy does not increase the frequency of HCMV infection in JRA patients, and (3) immunoincompetence might be one of the major factors contributing to increased susceptibility to HCMV infection in JRA and SLE patients.

Authors+Show Affiliations

Department of Pediatrics, National Taiwan University College of Medicine, Taipei, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7888786

Citation

Tsai, Y T., et al. "Detection of Epstein-Barr Virus and Cytomegalovirus Genome in White Blood Cells From Patients With Juvenile Rheumatoid Arthritis and Childhood Systemic Lupus Erythematosus." International Archives of Allergy and Immunology, vol. 106, no. 3, 1995, pp. 235-40.
Tsai YT, Chiang BL, Kao YF, et al. Detection of Epstein-Barr virus and cytomegalovirus genome in white blood cells from patients with juvenile rheumatoid arthritis and childhood systemic lupus erythematosus. Int Arch Allergy Immunol. 1995;106(3):235-40.
Tsai, Y. T., Chiang, B. L., Kao, Y. F., & Hsieh, K. H. (1995). Detection of Epstein-Barr virus and cytomegalovirus genome in white blood cells from patients with juvenile rheumatoid arthritis and childhood systemic lupus erythematosus. International Archives of Allergy and Immunology, 106(3), 235-40.
Tsai YT, et al. Detection of Epstein-Barr Virus and Cytomegalovirus Genome in White Blood Cells From Patients With Juvenile Rheumatoid Arthritis and Childhood Systemic Lupus Erythematosus. Int Arch Allergy Immunol. 1995;106(3):235-40. PubMed PMID: 7888786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Epstein-Barr virus and cytomegalovirus genome in white blood cells from patients with juvenile rheumatoid arthritis and childhood systemic lupus erythematosus. AU - Tsai,Y T, AU - Chiang,B L, AU - Kao,Y F, AU - Hsieh,K H, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 235 EP - 40 JF - International archives of allergy and immunology JO - Int Arch Allergy Immunol VL - 106 IS - 3 N2 - The role of infectious agents in the pathogenesis of autoimmune diseases has long been a matter of debate. This study investigated the possible role of Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) infections in the pathogenesis of autoimmune diseases by an attempt to demonstrate the presence of the viral genome in the leukocyte of 21 juvenile rheumatoid arthritis (JRA) patients, 20 childhood-onset systemic lupus erythematosus (SLE) patients, and 20 age-matched normals, using polymerase chain reaction (PCR) and DNA probes. The results showed: (1) there was no difference in serum IgG anti-EBV antibody titers among three groups; (2) the EBV PCR-positive rates for JRA and SLE patients and normal controls were 5% (1/21), 10 (2/20), and 0% (0/20), respectively; (3) the HCMV PCR-positive rates for JRA and SLE patients and normal controls were 33% (7/21), 25 (5/20), and 10% (2/20), respectively, and (4) the HCMV-positive rate was 25% for JRA patients with steroid treatment and 33% for those without steroid treatment. It is, therefore, concluded that: (1) the data do not support the participation of EBV and HCMV in the pathogenesis of childhood-onset SLE and JRA; (2) steroid therapy does not increase the frequency of HCMV infection in JRA patients, and (3) immunoincompetence might be one of the major factors contributing to increased susceptibility to HCMV infection in JRA and SLE patients. SN - 1018-2438 UR - https://www.unboundmedicine.com/medline/citation/7888786/Detection_of_Epstein_Barr_virus_and_cytomegalovirus_genome_in_white_blood_cells_from_patients_with_juvenile_rheumatoid_arthritis_and_childhood_systemic_lupus_erythematosus_ L2 - https://www.karger.com?DOI=10.1159/000236848 DB - PRIME DP - Unbound Medicine ER -