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Water soluble drug delivery systems based on a non-biological bioadhesive polymeric system.
Farmaco. 1994 Dec; 49(12):809-18.F

Abstract

Matrix properties and release behaviour of monolithic devices based on a water soluble polymer has been investigated. Polyethyleneoxides of different molecular weights have been used and different molecular weight fractions have been blended in order to tune the release mechanism. Drug release kinetics have been closely related to swelling and dissolution properties of the adopted matrices. In particular the development of the external swollen layer of the tablet as well as the kinetic of dissolution have been monitored. The different drug delivery behaviours observed were related to the different matrix properties. Viscoelastic properties of the matrices have been also investigated. In fact, in order to obtain effective bioadhesive drug release devices, apart from the intrinsic mucoadhesive capabilities of the used polymers, also the viscoelastic properties of the water-polymer gel must also be taken into account. A good interpenetration between the adjacent layers of the mucus and the polymer gel is ineffective in holding the mucoadhesive tablet at a specific site if the polymer gel does not have a proper viscoelastic behaviour. The best compromise between good release, viscoelatic and mucoadhesive properties was obtained in the case of 50% by weight blend of the two adopted polymer fractions (600,000 and 4,000,000 molecular weight).

Authors+Show Affiliations

Cappello B
Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Italy.
Del Nobile MA
No affiliation info available
La Rotonda MI
No affiliation info available
Mensitieri G
No affiliation info available
Miro A
No affiliation info available
Nicolais L
No affiliation info available

MeSH

Bronchodilator AgentsDrug Delivery SystemsKineticsPolyethylene GlycolsSolubilityTabletsTheophyllineWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7893338

Citation

Cappello, B, et al. "Water Soluble Drug Delivery Systems Based On a Non-biological Bioadhesive Polymeric System." Farmaco (Societa Chimica Italiana : 1989), vol. 49, no. 12, 1994, pp. 809-18.
Cappello B, Del Nobile MA, La Rotonda MI, et al. Water soluble drug delivery systems based on a non-biological bioadhesive polymeric system. Farmaco. 1994;49(12):809-18.
Cappello, B., Del Nobile, M. A., La Rotonda, M. I., Mensitieri, G., Miro, A., & Nicolais, L. (1994). Water soluble drug delivery systems based on a non-biological bioadhesive polymeric system. Farmaco (Societa Chimica Italiana : 1989), 49(12), 809-18.
Cappello B, et al. Water Soluble Drug Delivery Systems Based On a Non-biological Bioadhesive Polymeric System. Farmaco. 1994;49(12):809-18. PubMed PMID: 7893338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Water soluble drug delivery systems based on a non-biological bioadhesive polymeric system. AU - Cappello,B, AU - Del Nobile,M A, AU - La Rotonda,M I, AU - Mensitieri,G, AU - Miro,A, AU - Nicolais,L, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 809 EP - 18 JF - Farmaco (Societa chimica italiana : 1989) JO - Farmaco VL - 49 IS - 12 N2 - Matrix properties and release behaviour of monolithic devices based on a water soluble polymer has been investigated. Polyethyleneoxides of different molecular weights have been used and different molecular weight fractions have been blended in order to tune the release mechanism. Drug release kinetics have been closely related to swelling and dissolution properties of the adopted matrices. In particular the development of the external swollen layer of the tablet as well as the kinetic of dissolution have been monitored. The different drug delivery behaviours observed were related to the different matrix properties. Viscoelastic properties of the matrices have been also investigated. In fact, in order to obtain effective bioadhesive drug release devices, apart from the intrinsic mucoadhesive capabilities of the used polymers, also the viscoelastic properties of the water-polymer gel must also be taken into account. A good interpenetration between the adjacent layers of the mucus and the polymer gel is ineffective in holding the mucoadhesive tablet at a specific site if the polymer gel does not have a proper viscoelastic behaviour. The best compromise between good release, viscoelatic and mucoadhesive properties was obtained in the case of 50% by weight blend of the two adopted polymer fractions (600,000 and 4,000,000 molecular weight). SN - 0014-827X UR - https://www.unboundmedicine.com/medline/citation/7893338/Water_soluble_drug_delivery_systems_based_on_a_non_biological_bioadhesive_polymeric_system_ DB - PRIME DP - Unbound Medicine ER -