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Effects of infusion of parathyroid hormone and primary hyperparathyroidism on formation and breakdown of type I collagen.
Calcif Tissue Int. 1994 Dec; 55(6):412-6.CT

Abstract

The influence of chronic and acute exposure to parathyroid hormone (PTH) on formation and breakdown of type I collagen, using two recently developed radioimmunoassays for serum PICP (the carboxyterminal propeptide of type I procollagen) and serum ICTP (the carboxyterminal telopeptide of type I collagen), have been evaluated. Fasting morning values were obtained from 18 women with primary hyperparathyroidism (HPT) and an equal number of age-matched, healthy controls. A 24-hour infusion of synthetic human parathyroid hormone (PTH 1-38) was performed in 14 healthy females. The patients with HPT had higher values for serum ICTP than the controls (6.0 +/- 3.0 and 4.1 +/- 2.1 micrograms/liter; P < 0.05), whereas the serum PICP concentrations were not different (170 +/- 72 and 151 +/- 65 micrograms/liter; n.s.). During infusion of PTH in healthy subjects, there was an increase of the serum ICTP concentrations (from 3.6 +/- 1.3 to 4.4 +/- 1.8 micrograms/liter; P < 0.001) whereas those of serum PICP decreased (from 185 +/- 78 to 118 +/- 42 micrograms/liter; P < or = 0.0001). The increase of serum ICTP during infusion of PTH was positively related to the increase of serum calcium and other indices of bone resorption, i.e., fasting urinary excretions of hydroxyproline and calcium. The decrease of serum PICP was also related to the changes of serum ICTP and hydroxyproline in urine, serum calcium, and alkaline phosphatase but not to osteocalcin, an established marker of osteoblastic activity. The findings support the fact that serum ICTP is a valuable method for evaluating bone resorption and is also easy to perform.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Internal Medicine, University Hospital, Uppsala, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7895178

Citation

Brahm, H, et al. "Effects of Infusion of Parathyroid Hormone and Primary Hyperparathyroidism On Formation and Breakdown of Type I Collagen." Calcified Tissue International, vol. 55, no. 6, 1994, pp. 412-6.
Brahm H, Ljunggren O, Larsson K, et al. Effects of infusion of parathyroid hormone and primary hyperparathyroidism on formation and breakdown of type I collagen. Calcif Tissue Int. 1994;55(6):412-6.
Brahm, H., Ljunggren, O., Larsson, K., Lindh, E., & Ljunghall, S. (1994). Effects of infusion of parathyroid hormone and primary hyperparathyroidism on formation and breakdown of type I collagen. Calcified Tissue International, 55(6), 412-6.
Brahm H, et al. Effects of Infusion of Parathyroid Hormone and Primary Hyperparathyroidism On Formation and Breakdown of Type I Collagen. Calcif Tissue Int. 1994;55(6):412-6. PubMed PMID: 7895178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of infusion of parathyroid hormone and primary hyperparathyroidism on formation and breakdown of type I collagen. AU - Brahm,H, AU - Ljunggren,O, AU - Larsson,K, AU - Lindh,E, AU - Ljunghall,S, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 412 EP - 6 JF - Calcified tissue international JO - Calcif Tissue Int VL - 55 IS - 6 N2 - The influence of chronic and acute exposure to parathyroid hormone (PTH) on formation and breakdown of type I collagen, using two recently developed radioimmunoassays for serum PICP (the carboxyterminal propeptide of type I procollagen) and serum ICTP (the carboxyterminal telopeptide of type I collagen), have been evaluated. Fasting morning values were obtained from 18 women with primary hyperparathyroidism (HPT) and an equal number of age-matched, healthy controls. A 24-hour infusion of synthetic human parathyroid hormone (PTH 1-38) was performed in 14 healthy females. The patients with HPT had higher values for serum ICTP than the controls (6.0 +/- 3.0 and 4.1 +/- 2.1 micrograms/liter; P < 0.05), whereas the serum PICP concentrations were not different (170 +/- 72 and 151 +/- 65 micrograms/liter; n.s.). During infusion of PTH in healthy subjects, there was an increase of the serum ICTP concentrations (from 3.6 +/- 1.3 to 4.4 +/- 1.8 micrograms/liter; P < 0.001) whereas those of serum PICP decreased (from 185 +/- 78 to 118 +/- 42 micrograms/liter; P < or = 0.0001). The increase of serum ICTP during infusion of PTH was positively related to the increase of serum calcium and other indices of bone resorption, i.e., fasting urinary excretions of hydroxyproline and calcium. The decrease of serum PICP was also related to the changes of serum ICTP and hydroxyproline in urine, serum calcium, and alkaline phosphatase but not to osteocalcin, an established marker of osteoblastic activity. The findings support the fact that serum ICTP is a valuable method for evaluating bone resorption and is also easy to perform.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/7895178/Effects_of_infusion_of_parathyroid_hormone_and_primary_hyperparathyroidism_on_formation_and_breakdown_of_type_I_collagen_ L2 - http://www.diseaseinfosearch.org/result/3590 DB - PRIME DP - Unbound Medicine ER -