Tags

Type your tag names separated by a space and hit enter

Effects of vasodilating agents on cochlear blood flow in mice.
Hear Res. 1994 Nov; 80(2):241-6.HR

Abstract

The mouse has several distinct advantages as an experimental model for study of the cochlear blood flow (CBF) in the mammal, particularly for studies involving genetic manipulation, development and aging factors. In this investigation we evaluated the effects of selected vasodilating agents on CBF using laser-Doppler flowmetry. Sodium nitroprusside, hydralazine and pentoxifylline were applied topically on the round window (RW) or systemically by a subcutaneous injection. Topical application of sodium nitroprusside and hydralazine elevated CBF significantly, while systemic administrations of these two drugs failed to elevate CBF consistently. Pentoxifylline did not change CBF following topical application but increased CBF slightly following systemic administration. Age and gender did not influence the CBF response to topical application of sodium nitroprusside.

Authors+Show Affiliations

Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7896582

Citation

Nakashima, T, et al. "Effects of Vasodilating Agents On Cochlear Blood Flow in Mice." Hearing Research, vol. 80, no. 2, 1994, pp. 241-6.
Nakashima T, Nuttall AL, Miller JM. Effects of vasodilating agents on cochlear blood flow in mice. Hear Res. 1994;80(2):241-6.
Nakashima, T., Nuttall, A. L., & Miller, J. M. (1994). Effects of vasodilating agents on cochlear blood flow in mice. Hearing Research, 80(2), 241-6.
Nakashima T, Nuttall AL, Miller JM. Effects of Vasodilating Agents On Cochlear Blood Flow in Mice. Hear Res. 1994;80(2):241-6. PubMed PMID: 7896582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of vasodilating agents on cochlear blood flow in mice. AU - Nakashima,T, AU - Nuttall,A L, AU - Miller,J M, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 241 EP - 6 JF - Hearing research JO - Hear. Res. VL - 80 IS - 2 N2 - The mouse has several distinct advantages as an experimental model for study of the cochlear blood flow (CBF) in the mammal, particularly for studies involving genetic manipulation, development and aging factors. In this investigation we evaluated the effects of selected vasodilating agents on CBF using laser-Doppler flowmetry. Sodium nitroprusside, hydralazine and pentoxifylline were applied topically on the round window (RW) or systemically by a subcutaneous injection. Topical application of sodium nitroprusside and hydralazine elevated CBF significantly, while systemic administrations of these two drugs failed to elevate CBF consistently. Pentoxifylline did not change CBF following topical application but increased CBF slightly following systemic administration. Age and gender did not influence the CBF response to topical application of sodium nitroprusside. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/7896582/Effects_of_vasodilating_agents_on_cochlear_blood_flow_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-5955(94)90115-5 DB - PRIME DP - Unbound Medicine ER -