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Case study: paradoxical response to naltrexone treatment of self-injurious behavior.
J Am Acad Child Adolesc Psychiatry. 1995 Feb; 34(2):238-42.JA

Abstract

Opioid receptor antagonists have been studied in the management of self-injurious behavior (SIB) in developmentally disabled individuals. The authors present a case of a severely retarded, autistic man whose SIB increased dramatically during a trial of naltrexone. A paradoxical increase in SIB, attributed to the extinction burst phenomenon during the initial period of nonreward, is known to occur during treatment with naloxone, a short-acting parenteral opioid antagonist. It has only once been reported during treatment with naltrexone, a long-acting orally administered agent. Opioid analgesic effects and learning theory can explain both increases and decreases in SIB after opioid blockade.

Authors+Show Affiliations

Department of Psychiatry, University of Massachusetts Medical Center, Worcester 01655.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7896657

Citation

Benjamin, S, et al. "Case Study: Paradoxical Response to Naltrexone Treatment of Self-injurious Behavior." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 34, no. 2, 1995, pp. 238-42.
Benjamin S, Seek A, Tresise L, et al. Case study: paradoxical response to naltrexone treatment of self-injurious behavior. J Am Acad Child Adolesc Psychiatry. 1995;34(2):238-42.
Benjamin, S., Seek, A., Tresise, L., Price, E., & Gagnon, M. (1995). Case study: paradoxical response to naltrexone treatment of self-injurious behavior. Journal of the American Academy of Child and Adolescent Psychiatry, 34(2), 238-42.
Benjamin S, et al. Case Study: Paradoxical Response to Naltrexone Treatment of Self-injurious Behavior. J Am Acad Child Adolesc Psychiatry. 1995;34(2):238-42. PubMed PMID: 7896657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case study: paradoxical response to naltrexone treatment of self-injurious behavior. AU - Benjamin,S, AU - Seek,A, AU - Tresise,L, AU - Price,E, AU - Gagnon,M, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 238 EP - 42 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 34 IS - 2 N2 - Opioid receptor antagonists have been studied in the management of self-injurious behavior (SIB) in developmentally disabled individuals. The authors present a case of a severely retarded, autistic man whose SIB increased dramatically during a trial of naltrexone. A paradoxical increase in SIB, attributed to the extinction burst phenomenon during the initial period of nonreward, is known to occur during treatment with naloxone, a short-acting parenteral opioid antagonist. It has only once been reported during treatment with naltrexone, a long-acting orally administered agent. Opioid analgesic effects and learning theory can explain both increases and decreases in SIB after opioid blockade. SN - 0890-8567 UR - https://www.unboundmedicine.com/medline/citation/7896657/Case_study:_paradoxical_response_to_naltrexone_treatment_of_self_injurious_behavior_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(09)63763-1 DB - PRIME DP - Unbound Medicine ER -