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Aspects of canine distemper virus and measles virus encephalomyelitis.
Neuropathol Appl Neurobiol. 1994 Dec; 20(6):525-34.NA

Abstract

Canine distemper (CD) is a frequently fatal, systemic morbillivirus infection in the dog and other carnivores: encephalomyelitis is the common cause of death. Susceptibility to canine distemper virus (CDV) is now recognized in a wide range of non-domestic animals, most recently in captive lions, tigers and leopards. Furthermore, closely related viruses have produced CD-like diseases in marine mammals. CDV induces an inclusion-body encephalomyelitis in the dog and demyelination is often a conspicuous feature. Myelin injury is associated with the presence of virus but the mechanism of demyelination remains incompletely understood. Oligodendrocyte infection may be defective, as has been shown in vitro. CDV and measles virus (MV) produce similar systemic disorders in their respective hosts but differ markedly in the frequency of central nervous system (CNS) involvement, and in the pathogenesis of the more common neurological sequelae. Both CDV and MV have been considered as multiple sclerosis agents, and the association of CDV with other human disease has been suggested.

Authors+Show Affiliations

Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

7898614

Citation

Summers, B A., and M J. Appel. "Aspects of Canine Distemper Virus and Measles Virus Encephalomyelitis." Neuropathology and Applied Neurobiology, vol. 20, no. 6, 1994, pp. 525-34.
Summers BA, Appel MJ. Aspects of canine distemper virus and measles virus encephalomyelitis. Neuropathol Appl Neurobiol. 1994;20(6):525-34.
Summers, B. A., & Appel, M. J. (1994). Aspects of canine distemper virus and measles virus encephalomyelitis. Neuropathology and Applied Neurobiology, 20(6), 525-34.
Summers BA, Appel MJ. Aspects of Canine Distemper Virus and Measles Virus Encephalomyelitis. Neuropathol Appl Neurobiol. 1994;20(6):525-34. PubMed PMID: 7898614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aspects of canine distemper virus and measles virus encephalomyelitis. AU - Summers,B A, AU - Appel,M J, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 525 EP - 34 JF - Neuropathology and applied neurobiology JO - Neuropathol. Appl. Neurobiol. VL - 20 IS - 6 N2 - Canine distemper (CD) is a frequently fatal, systemic morbillivirus infection in the dog and other carnivores: encephalomyelitis is the common cause of death. Susceptibility to canine distemper virus (CDV) is now recognized in a wide range of non-domestic animals, most recently in captive lions, tigers and leopards. Furthermore, closely related viruses have produced CD-like diseases in marine mammals. CDV induces an inclusion-body encephalomyelitis in the dog and demyelination is often a conspicuous feature. Myelin injury is associated with the presence of virus but the mechanism of demyelination remains incompletely understood. Oligodendrocyte infection may be defective, as has been shown in vitro. CDV and measles virus (MV) produce similar systemic disorders in their respective hosts but differ markedly in the frequency of central nervous system (CNS) involvement, and in the pathogenesis of the more common neurological sequelae. Both CDV and MV have been considered as multiple sclerosis agents, and the association of CDV with other human disease has been suggested. SN - 0305-1846 UR - https://www.unboundmedicine.com/medline/citation/7898614/Aspects_of_canine_distemper_virus_and_measles_virus_encephalomyelitis_ L2 - https://doi.org/10.1111/j.1365-2990.1994.tb01006.x DB - PRIME DP - Unbound Medicine ER -