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Mechanism of thirst attenuation during head-out water immersion in men.
Am J Physiol. 1995 Mar; 268(3 Pt 2):R583-9.AJ

Abstract

The purpose was to determine whether extracellular volume or osmolality was the major contributing factor for reduction of thirst in air and head-out water immersion in hypohydrated subjects. Eight males (19-25 yr) were subjected to thermoneutral immersion and thermoneutral air under two hydration conditions without further drinking: euhydration in water (Eu-H2O) and euhydration in air, and hypohydration in water (Hypo-H2O) and hypohydration in air (3.7% wt loss after exercise in heat). The increased thirst sensation with Hypo-H2O decreased (P < 0.05) within 10 min of immersion and continued thereafter. Mean plasma osmolality (288 +/- 1 mosmol/kgH2O) and sodium (140 +/- 1 meq/l) remained elevated, and plasma volume increased by 4.2 +/- 1.0% (P < 0.05) throughout Hypo-H2O. A sustained increase (P < 0.05) in stroke volume accompanied the prompt and sustained decrease in plasma renin activity and sustained increase (P < 0.05) in plasma atrial natriuretic peptide during Eu-H2O and Hypo-H2O. Plasma vasopressin decreased from 5.3 +/- 0.7 to 2.9 +/- 0.5 pg/ml (P < 0.05) during Hypo-H2O but was unchanged in Eu-H2O. These findings suggest a sustained stimulation of the atrial baroreceptors and reduction of a dipsogenic stimulus without major alterations of extracellular osmolality in Hypo-H2O. Thus it appears that vascular volume-induced stimuli of cardiopulmonary baroreceptors play a more important role than extracellular osmolality in reducing thirst sensations during immersion in hypohydrated subjects.

Authors+Show Affiliations

Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7900899

Citation

Wada, F, et al. "Mechanism of Thirst Attenuation During Head-out Water Immersion in Men." The American Journal of Physiology, vol. 268, no. 3 Pt 2, 1995, pp. R583-9.
Wada F, Sagawa S, Miki K, et al. Mechanism of thirst attenuation during head-out water immersion in men. Am J Physiol. 1995;268(3 Pt 2):R583-9.
Wada, F., Sagawa, S., Miki, K., Nagaya, K., Nakamitsu, S., Shiraki, K., & Greenleaf, J. E. (1995). Mechanism of thirst attenuation during head-out water immersion in men. The American Journal of Physiology, 268(3 Pt 2), R583-9.
Wada F, et al. Mechanism of Thirst Attenuation During Head-out Water Immersion in Men. Am J Physiol. 1995;268(3 Pt 2):R583-9. PubMed PMID: 7900899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanism of thirst attenuation during head-out water immersion in men. AU - Wada,F, AU - Sagawa,S, AU - Miki,K, AU - Nagaya,K, AU - Nakamitsu,S, AU - Shiraki,K, AU - Greenleaf,J E, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez KW - NASA Center ARC KW - NASA Discipline Number 18-10 KW - NASA Discipline Regulatory Physiology KW - NASA Program Space Physiology and Countermeasures SP - R583 EP - 9 JF - The American journal of physiology JO - Am. J. Physiol. VL - 268 IS - 3 Pt 2 N2 - The purpose was to determine whether extracellular volume or osmolality was the major contributing factor for reduction of thirst in air and head-out water immersion in hypohydrated subjects. Eight males (19-25 yr) were subjected to thermoneutral immersion and thermoneutral air under two hydration conditions without further drinking: euhydration in water (Eu-H2O) and euhydration in air, and hypohydration in water (Hypo-H2O) and hypohydration in air (3.7% wt loss after exercise in heat). The increased thirst sensation with Hypo-H2O decreased (P < 0.05) within 10 min of immersion and continued thereafter. Mean plasma osmolality (288 +/- 1 mosmol/kgH2O) and sodium (140 +/- 1 meq/l) remained elevated, and plasma volume increased by 4.2 +/- 1.0% (P < 0.05) throughout Hypo-H2O. A sustained increase (P < 0.05) in stroke volume accompanied the prompt and sustained decrease in plasma renin activity and sustained increase (P < 0.05) in plasma atrial natriuretic peptide during Eu-H2O and Hypo-H2O. Plasma vasopressin decreased from 5.3 +/- 0.7 to 2.9 +/- 0.5 pg/ml (P < 0.05) during Hypo-H2O but was unchanged in Eu-H2O. These findings suggest a sustained stimulation of the atrial baroreceptors and reduction of a dipsogenic stimulus without major alterations of extracellular osmolality in Hypo-H2O. Thus it appears that vascular volume-induced stimuli of cardiopulmonary baroreceptors play a more important role than extracellular osmolality in reducing thirst sensations during immersion in hypohydrated subjects. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/7900899/Mechanism_of_thirst_attenuation_during_head_out_water_immersion_in_men_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpregu.1995.268.3.R583?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -