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Serotonin and myoclonus.
Monogr Neural Sci. 1976; 3:71-80.MN

Abstract

Biochemical studies of serotonin metabolism and a therapeutic trial of L-5-hydroxytryptophan (L-5-HTP) in combination with carbidopa were carried out in 19 patients with myoclonus. In 6 patients with intention myoclonus, the cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, a metabolite of serotonin was found to be significantly decreased. L-5-HTP with carbidopa dramatically decreased the frequency and intensity of myoclonus, particularly in those patients with a diagnosis of postanoxic intention myoclonus. The major side effects have been anorexia, nausea, vomiting, diarrhea and mental stimulation. We suggest that a deficiency of brain serotonin is causally related to myoclonic muscle movements and the therapeutic efficacy of L-5-HTP plus carbidopa may be due to the repletion of serotonin in regions of the brain where serotoninergic neurons have degenerated.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

790170

Citation

Van Woert, M H., et al. "Serotonin and Myoclonus." Monographs in Neural Sciences, vol. 3, 1976, pp. 71-80.
Van Woert MH, Jutkowitz R, Rosenbaum D, et al. Serotonin and myoclonus. Monogr Neural Sci. 1976;3:71-80.
Van Woert, M. H., Jutkowitz, R., Rosenbaum, D., & Bowers, M. B. (1976). Serotonin and myoclonus. Monographs in Neural Sciences, 3, 71-80.
Van Woert MH, et al. Serotonin and Myoclonus. Monogr Neural Sci. 1976;3:71-80. PubMed PMID: 790170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serotonin and myoclonus. AU - Van Woert,M H, AU - Jutkowitz,R, AU - Rosenbaum,D, AU - Bowers,M B,Jr PY - 1976/1/1/pubmed PY - 2001/3/28/medline PY - 1976/1/1/entrez SP - 71 EP - 80 JF - Monographs in neural sciences JO - Monogr Neural Sci VL - 3 N2 - Biochemical studies of serotonin metabolism and a therapeutic trial of L-5-hydroxytryptophan (L-5-HTP) in combination with carbidopa were carried out in 19 patients with myoclonus. In 6 patients with intention myoclonus, the cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, a metabolite of serotonin was found to be significantly decreased. L-5-HTP with carbidopa dramatically decreased the frequency and intensity of myoclonus, particularly in those patients with a diagnosis of postanoxic intention myoclonus. The major side effects have been anorexia, nausea, vomiting, diarrhea and mental stimulation. We suggest that a deficiency of brain serotonin is causally related to myoclonic muscle movements and the therapeutic efficacy of L-5-HTP plus carbidopa may be due to the repletion of serotonin in regions of the brain where serotoninergic neurons have degenerated. SN - 0300-5186 UR - https://www.unboundmedicine.com/medline/citation/790170/Serotonin_and_myoclonus_ L2 - http://www.diseaseinfosearch.org/result/5032 DB - PRIME DP - Unbound Medicine ER -