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Rectal epithelial gamma/delta T-lymphocyte responses to local gluten challenge in coeliac disease.
Scand J Gastroenterol. 1993 Sep; 28(9):760-2.SJ

Abstract

The proportion of intra-epithelial lymphocytes (IEL) that utilize the gamma/delta form of the T-cell receptor (TCR) is increased in coeliac disease, but their function remains unexplained. The response of intra-epithelial lymphocytes to rectal gluten challenge in coeliac and control subjects was studied after a rectal challenge of 2 g of Frazer's fraction III. A marked rise in CD3+ IEL occurred after challenge in the coeliac patients, peaking at 6 h and returning to normal by 48 h, with no significant changes in the gamma/delta TCR+ IEL. The IEL did not significantly change after gluten challenge in the controls. Acute gluten challenge induces infiltration of the rectal mucosa by T cells in coeliac patients, which is not accompanied acutely by increased numbers of gamma/delta TCR+ IEL. This study supports the hypothesis that alpha/beta TCR+ T cells may be of importance in the early response of coeliac patients to local gluten challenge.

Authors+Show Affiliations

Rayne Institute, St Thomas's Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7901891

Citation

Sturgess, R P., et al. "Rectal Epithelial Gamma/delta T-lymphocyte Responses to Local Gluten Challenge in Coeliac Disease." Scandinavian Journal of Gastroenterology, vol. 28, no. 9, 1993, pp. 760-2.
Sturgess RP, Loft D, Kontakou M, et al. Rectal epithelial gamma/delta T-lymphocyte responses to local gluten challenge in coeliac disease. Scand J Gastroenterol. 1993;28(9):760-2.
Sturgess, R. P., Loft, D., Kontakou, M., Crowe, P., Marsh, M. N., & Ciclitira, P. J. (1993). Rectal epithelial gamma/delta T-lymphocyte responses to local gluten challenge in coeliac disease. Scandinavian Journal of Gastroenterology, 28(9), 760-2.
Sturgess RP, et al. Rectal Epithelial Gamma/delta T-lymphocyte Responses to Local Gluten Challenge in Coeliac Disease. Scand J Gastroenterol. 1993;28(9):760-2. PubMed PMID: 7901891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rectal epithelial gamma/delta T-lymphocyte responses to local gluten challenge in coeliac disease. AU - Sturgess,R P, AU - Loft,D, AU - Kontakou,M, AU - Crowe,P, AU - Marsh,M N, AU - Ciclitira,P J, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 760 EP - 2 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 28 IS - 9 N2 - The proportion of intra-epithelial lymphocytes (IEL) that utilize the gamma/delta form of the T-cell receptor (TCR) is increased in coeliac disease, but their function remains unexplained. The response of intra-epithelial lymphocytes to rectal gluten challenge in coeliac and control subjects was studied after a rectal challenge of 2 g of Frazer's fraction III. A marked rise in CD3+ IEL occurred after challenge in the coeliac patients, peaking at 6 h and returning to normal by 48 h, with no significant changes in the gamma/delta TCR+ IEL. The IEL did not significantly change after gluten challenge in the controls. Acute gluten challenge induces infiltration of the rectal mucosa by T cells in coeliac patients, which is not accompanied acutely by increased numbers of gamma/delta TCR+ IEL. This study supports the hypothesis that alpha/beta TCR+ T cells may be of importance in the early response of coeliac patients to local gluten challenge. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/7901891/Rectal_epithelial_gamma/delta_T_lymphocyte_responses_to_local_gluten_challenge_in_coeliac_disease_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365529309104004 DB - PRIME DP - Unbound Medicine ER -