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Gastroesophageal varices: prevention of bleeding and rebleeding.
Gastroenterol Clin North Am. 1993 Dec; 22(4):801-20.GC

Abstract

Nonselective beta-adrenergic blockers (propranolol and nadolol) are effective in preventing initial variceal hemorrhage, although their influence on improving survival is less dramatic. There is no role for either sclerotherapy or prophylactic portosystemic shunts for the prevention of initial variceal hemorrhage. Both endoscopic therapy (sclerotherapy, esophageal variceal ligation) and nonselective beta-adrenergic blockers are effective in reducing the risk of recurrent bleeding related to portal hypertension; however, there are significant numbers of failures with both approaches, and the effect on survival is less impressive. Randomized controlled trials evaluating each of these therapeutic options are reviewed in this article.

Authors+Show Affiliations

Tufts University School of Medicine, Boston, Massachusetts.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

7905864

Citation

Lopes, G M., and N D. Grace. "Gastroesophageal Varices: Prevention of Bleeding and Rebleeding." Gastroenterology Clinics of North America, vol. 22, no. 4, 1993, pp. 801-20.
Lopes GM, Grace ND. Gastroesophageal varices: prevention of bleeding and rebleeding. Gastroenterol Clin North Am. 1993;22(4):801-20.
Lopes, G. M., & Grace, N. D. (1993). Gastroesophageal varices: prevention of bleeding and rebleeding. Gastroenterology Clinics of North America, 22(4), 801-20.
Lopes GM, Grace ND. Gastroesophageal Varices: Prevention of Bleeding and Rebleeding. Gastroenterol Clin North Am. 1993;22(4):801-20. PubMed PMID: 7905864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroesophageal varices: prevention of bleeding and rebleeding. AU - Lopes,G M, AU - Grace,N D, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 801 EP - 20 JF - Gastroenterology clinics of North America JO - Gastroenterol Clin North Am VL - 22 IS - 4 N2 - Nonselective beta-adrenergic blockers (propranolol and nadolol) are effective in preventing initial variceal hemorrhage, although their influence on improving survival is less dramatic. There is no role for either sclerotherapy or prophylactic portosystemic shunts for the prevention of initial variceal hemorrhage. Both endoscopic therapy (sclerotherapy, esophageal variceal ligation) and nonselective beta-adrenergic blockers are effective in reducing the risk of recurrent bleeding related to portal hypertension; however, there are significant numbers of failures with both approaches, and the effect on survival is less impressive. Randomized controlled trials evaluating each of these therapeutic options are reviewed in this article. SN - 0889-8553 UR - https://www.unboundmedicine.com/medline/citation/7905864/Gastroesophageal_varices:_prevention_of_bleeding_and_rebleeding_ DB - PRIME DP - Unbound Medicine ER -