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Evaluation of kidney and liver subacute toxicity of antitumor agents using serum biochemical parameters in rats.
Biochem Mol Biol Int. 1993 Nov; 31(3):565-73.BM

Abstract

Hepatic and renal subacute toxicity induced by the antineoplastic drugs chlorambucil, cisplatin, epirubicin and methotrexate and the steroid alkylating agent 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13, 17-lactam (p-[bis(2-chloroethyl) amino] phenyl) acetate was investigated in rats using serum biochemical parameters. Toxicological evaluation was performed in serum samples following the administration of dose regimens of the agents that were previously shown to be effective in suppressing malignant tumor growth or to prolong survival in tumor bearing animals. Hepatic and renal subacute toxicity was evaluated by measuring enzyme activity or concentrations of: alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, total cholesterol, gamma-glutamyltransferase, glucose, potassium, sodium, blood urea nitrogen and uric acid. The use of the above serum biochemical parameters indicated that the overall toxicity impact of the antitumor drugs was methotrexate < cisplatin < epirubicin < chlorambucil. The homo-azasteroid ester only transiently affected the biochemical parameters associated with renal toxicity, while it affected some of the biochemical parameters associated with hepatic toxicity, though to a significantly lower extent than the antitumor drugs.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Patras, Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7906982

Citation

Pispirigos, K, et al. "Evaluation of Kidney and Liver Subacute Toxicity of Antitumor Agents Using Serum Biochemical Parameters in Rats." Biochemistry and Molecular Biology International, vol. 31, no. 3, 1993, pp. 565-73.
Pispirigos K, Catsoulakos P, Karakiulakis G. Evaluation of kidney and liver subacute toxicity of antitumor agents using serum biochemical parameters in rats. Biochem Mol Biol Int. 1993;31(3):565-73.
Pispirigos, K., Catsoulakos, P., & Karakiulakis, G. (1993). Evaluation of kidney and liver subacute toxicity of antitumor agents using serum biochemical parameters in rats. Biochemistry and Molecular Biology International, 31(3), 565-73.
Pispirigos K, Catsoulakos P, Karakiulakis G. Evaluation of Kidney and Liver Subacute Toxicity of Antitumor Agents Using Serum Biochemical Parameters in Rats. Biochem Mol Biol Int. 1993;31(3):565-73. PubMed PMID: 7906982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of kidney and liver subacute toxicity of antitumor agents using serum biochemical parameters in rats. AU - Pispirigos,K, AU - Catsoulakos,P, AU - Karakiulakis,G, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 565 EP - 73 JF - Biochemistry and molecular biology international JO - Biochem Mol Biol Int VL - 31 IS - 3 N2 - Hepatic and renal subacute toxicity induced by the antineoplastic drugs chlorambucil, cisplatin, epirubicin and methotrexate and the steroid alkylating agent 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13, 17-lactam (p-[bis(2-chloroethyl) amino] phenyl) acetate was investigated in rats using serum biochemical parameters. Toxicological evaluation was performed in serum samples following the administration of dose regimens of the agents that were previously shown to be effective in suppressing malignant tumor growth or to prolong survival in tumor bearing animals. Hepatic and renal subacute toxicity was evaluated by measuring enzyme activity or concentrations of: alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, total cholesterol, gamma-glutamyltransferase, glucose, potassium, sodium, blood urea nitrogen and uric acid. The use of the above serum biochemical parameters indicated that the overall toxicity impact of the antitumor drugs was methotrexate < cisplatin < epirubicin < chlorambucil. The homo-azasteroid ester only transiently affected the biochemical parameters associated with renal toxicity, while it affected some of the biochemical parameters associated with hepatic toxicity, though to a significantly lower extent than the antitumor drugs. SN - 1039-9712 UR - https://www.unboundmedicine.com/medline/citation/7906982/Evaluation_of_kidney_and_liver_subacute_toxicity_of_antitumor_agents_using_serum_biochemical_parameters_in_rats_ L2 - https://medlineplus.gov/drugreactions.html DB - PRIME DP - Unbound Medicine ER -