Type your tag names separated by a space and hit enter

Psychopharmacologic treatment of negative schizophrenic symptoms.

Abstract

Diverse pharmacologic agents have been reported to be effective in treating negative schizophrenic symptoms (NSS). In light of this large and growing literature, as well as of reconceptualizations of the underlying pathophysiology of NSS, the time may have come to reject models that assume "irreversibility" of NSS. However, flaws in existing studies prevent closure regarding the reversibility of, and by inference the treatability of, NSS. Guidelines for future studies are articulated, e.g., the need to distinguish primary from secondary NSS, to include drug-free subjects with a predominance of NSS in clinical trials, and to use well-validated and psychometrically sound instruments for assessing NSS.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY.

    ,

    Source

    MeSH

    Antipsychotic Agents
    Brain
    Drug Therapy, Combination
    Humans
    Psychiatric Status Rating Scales
    Psychotropic Drugs
    Schizophrenia
    Schizophrenic Psychology

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    7908618

    Citation

    Opler, L A., et al. "Psychopharmacologic Treatment of Negative Schizophrenic Symptoms." Comprehensive Psychiatry, vol. 35, no. 1, 1994, pp. 16-28.
    Opler LA, Albert D, Ramirez PM. Psychopharmacologic treatment of negative schizophrenic symptoms. Compr Psychiatry. 1994;35(1):16-28.
    Opler, L. A., Albert, D., & Ramirez, P. M. (1994). Psychopharmacologic treatment of negative schizophrenic symptoms. Comprehensive Psychiatry, 35(1), pp. 16-28.
    Opler LA, Albert D, Ramirez PM. Psychopharmacologic Treatment of Negative Schizophrenic Symptoms. Compr Psychiatry. 1994;35(1):16-28. PubMed PMID: 7908618.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Psychopharmacologic treatment of negative schizophrenic symptoms. AU - Opler,L A, AU - Albert,D, AU - Ramirez,P M, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 16 EP - 28 JF - Comprehensive psychiatry JO - Compr Psychiatry VL - 35 IS - 1 N2 - Diverse pharmacologic agents have been reported to be effective in treating negative schizophrenic symptoms (NSS). In light of this large and growing literature, as well as of reconceptualizations of the underlying pathophysiology of NSS, the time may have come to reject models that assume "irreversibility" of NSS. However, flaws in existing studies prevent closure regarding the reversibility of, and by inference the treatability of, NSS. Guidelines for future studies are articulated, e.g., the need to distinguish primary from secondary NSS, to include drug-free subjects with a predominance of NSS in clinical trials, and to use well-validated and psychometrically sound instruments for assessing NSS. SN - 0010-440X UR - https://www.unboundmedicine.com/medline/citation/7908618/Psychopharmacologic_treatment_of_negative_schizophrenic_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-440X(94)90165-1 DB - PRIME DP - Unbound Medicine ER -