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Central effects of repeated treatment with CGP 37849, a competitive NMDA receptor antagonist with potential antidepressant activity.
Pol J Pharmacol. 1993 Sep-Dec; 45(5-6):455-66.PJ

Abstract

CGP 37849, a competitive NMDA receptor antagonist, was administered repeatedly (10 mg/kg po, twice daily for 14 days) to male Wistar rats. In behavioral studies it did not affect the locomotor activity, but enhanced the d-amphetamine-induced hyperactivity. Biochemical studies of the concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), noradrenaline (NA), 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) in the rat cerebral cortex, striatum and nucleus accumbens showed that only the concentrations of DOPAC (an increase) and NA (a decrease) were changed in the nucleus accumbens. Repeated administration of CGP 37849 increased the density of dopamine D1 receptors labelled with [3H]-SCH 23390 in the rat striatum, but not in the limbic forebrain, having exerted no effect on the density of D2 receptors labelled with [3H]-spiperone. The density of alpha 1- and beta-adrenoceptors, labelled with [3H]-prazosin and [3H]-dihydroalprenolol, respectively, were unchanged in the cerebral cortex. The obtained results indicate that in some experimental paradigms CGP 37849 given repeatedly produces effects similar to those of typical antidepressant drugs.

Authors+Show Affiliations

Institute of Pharmacology, Polish Academy of Sciences, Kraków.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7912134

Citation

Maj, J, et al. "Central Effects of Repeated Treatment With CGP 37849, a Competitive NMDA Receptor Antagonist With Potential Antidepressant Activity." Polish Journal of Pharmacology, vol. 45, no. 5-6, 1993, pp. 455-66.
Maj J, Klimek V, Gołembiowska K, et al. Central effects of repeated treatment with CGP 37849, a competitive NMDA receptor antagonist with potential antidepressant activity. Pol J Pharmacol. 1993;45(5-6):455-66.
Maj, J., Klimek, V., Gołembiowska, K., Rogóz, Z., & Skuza, G. (1993). Central effects of repeated treatment with CGP 37849, a competitive NMDA receptor antagonist with potential antidepressant activity. Polish Journal of Pharmacology, 45(5-6), 455-66.
Maj J, et al. Central Effects of Repeated Treatment With CGP 37849, a Competitive NMDA Receptor Antagonist With Potential Antidepressant Activity. Pol J Pharmacol. 1993 Sep-Dec;45(5-6):455-66. PubMed PMID: 7912134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central effects of repeated treatment with CGP 37849, a competitive NMDA receptor antagonist with potential antidepressant activity. AU - Maj,J, AU - Klimek,V, AU - Gołembiowska,K, AU - Rogóz,Z, AU - Skuza,G, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 455 EP - 66 JF - Polish journal of pharmacology JO - Pol J Pharmacol VL - 45 IS - 5-6 N2 - CGP 37849, a competitive NMDA receptor antagonist, was administered repeatedly (10 mg/kg po, twice daily for 14 days) to male Wistar rats. In behavioral studies it did not affect the locomotor activity, but enhanced the d-amphetamine-induced hyperactivity. Biochemical studies of the concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), noradrenaline (NA), 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) in the rat cerebral cortex, striatum and nucleus accumbens showed that only the concentrations of DOPAC (an increase) and NA (a decrease) were changed in the nucleus accumbens. Repeated administration of CGP 37849 increased the density of dopamine D1 receptors labelled with [3H]-SCH 23390 in the rat striatum, but not in the limbic forebrain, having exerted no effect on the density of D2 receptors labelled with [3H]-spiperone. The density of alpha 1- and beta-adrenoceptors, labelled with [3H]-prazosin and [3H]-dihydroalprenolol, respectively, were unchanged in the cerebral cortex. The obtained results indicate that in some experimental paradigms CGP 37849 given repeatedly produces effects similar to those of typical antidepressant drugs. SN - 1230-6002 UR - https://www.unboundmedicine.com/medline/citation/7912134/Central_effects_of_repeated_treatment_with_CGP_37849_a_competitive_NMDA_receptor_antagonist_with_potential_antidepressant_activity_ L2 - https://medlineplus.gov/antidepressants.html DB - PRIME DP - Unbound Medicine ER -