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Beta-adrenergic regulation of the somatostatinergic system in rat hippocampus.
Neurosci Lett. 1994 Jan 03; 165(1-2):27-32.NL

Abstract

Interaction of beta-adrenergic and somatostatinergic systems in the hippocampus has not been investigated fully. We studied the influence of DL-isoproterenol (ISO), a beta-adrenergic agonist and DL-propranolol (PRO), a beta-adrenergic blocking agent, on the somatostatinergic system in the rat hippocampus. The short-(5h) and long-term (14 days) administration of ISO (5 mg/kg i.p.) or of PRO (10 mg/kg i.p.) did not affect somatostatin-like immunoreactivity (SSLI) content in the hippocampus of male Wistar rats. Both short- and long-term ISO administration decreased the number of specific [125I]Tyr11-somatostatin ([125I]Tyr11-SS) receptors in synaptosomes from hippocampus (29%, P < 0.05 and 34%, P < 0.05, after short- and long-term administration, respectively) without changing the affinity constant. This decrease in the number of [125I]Tyr11-SS receptors was not due to a direct effect of ISO on these receptors since no decrease in binding was produced by high concentrations of ISO (10(-5) M) when added in vitro. In addition, this decrease could be blocked by pretreatment with PRO. Short- and long-term administration of PRO alone increased the [125I]Tyr11-SS binding in hippocampus (42%, P < 0.05 and 33%, P < 0.05, after short- or long-term administration, respectively) without changing the affinity constant. Although there is no direct evidence that the regulation of SS receptors by the beta-adrenergic system has a physiological significance, this mechanism may provide a means by which the brain environment could modulate SS receptor number and, therefore, sensitivity to SS in a subset of SS-sensitive neurons.

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Authors+Show Affiliations

López-Sañudo S
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Arilla E
No affiliation info available

MeSH

AnimalsHippocampusIn Vitro TechniquesIodine RadioisotopesIsoproterenolMalePropranololRatsRats, WistarReceptors, Adrenergic, betaReceptors, SomatostatinSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7912420

Citation

López-Sañudo, S, and E Arilla. "Beta-adrenergic Regulation of the Somatostatinergic System in Rat Hippocampus." Neuroscience Letters, vol. 165, no. 1-2, 1994, pp. 27-32.
López-Sañudo S, Arilla E. Beta-adrenergic regulation of the somatostatinergic system in rat hippocampus. Neurosci Lett. 1994;165(1-2):27-32.
López-Sañudo, S., & Arilla, E. (1994). Beta-adrenergic regulation of the somatostatinergic system in rat hippocampus. Neuroscience Letters, 165(1-2), 27-32.
López-Sañudo S, Arilla E. Beta-adrenergic Regulation of the Somatostatinergic System in Rat Hippocampus. Neurosci Lett. 1994 Jan 3;165(1-2):27-32. PubMed PMID: 7912420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beta-adrenergic regulation of the somatostatinergic system in rat hippocampus. AU - López-Sañudo,S, AU - Arilla,E, PY - 1994/1/3/pubmed PY - 1994/1/3/medline PY - 1994/1/3/entrez SP - 27 EP - 32 JF - Neuroscience letters JO - Neurosci Lett VL - 165 IS - 1-2 N2 - Interaction of beta-adrenergic and somatostatinergic systems in the hippocampus has not been investigated fully. We studied the influence of DL-isoproterenol (ISO), a beta-adrenergic agonist and DL-propranolol (PRO), a beta-adrenergic blocking agent, on the somatostatinergic system in the rat hippocampus. The short-(5h) and long-term (14 days) administration of ISO (5 mg/kg i.p.) or of PRO (10 mg/kg i.p.) did not affect somatostatin-like immunoreactivity (SSLI) content in the hippocampus of male Wistar rats. Both short- and long-term ISO administration decreased the number of specific [125I]Tyr11-somatostatin ([125I]Tyr11-SS) receptors in synaptosomes from hippocampus (29%, P < 0.05 and 34%, P < 0.05, after short- and long-term administration, respectively) without changing the affinity constant. This decrease in the number of [125I]Tyr11-SS receptors was not due to a direct effect of ISO on these receptors since no decrease in binding was produced by high concentrations of ISO (10(-5) M) when added in vitro. In addition, this decrease could be blocked by pretreatment with PRO. Short- and long-term administration of PRO alone increased the [125I]Tyr11-SS binding in hippocampus (42%, P < 0.05 and 33%, P < 0.05, after short- or long-term administration, respectively) without changing the affinity constant. Although there is no direct evidence that the regulation of SS receptors by the beta-adrenergic system has a physiological significance, this mechanism may provide a means by which the brain environment could modulate SS receptor number and, therefore, sensitivity to SS in a subset of SS-sensitive neurons. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/7912420/Beta_adrenergic_regulation_of_the_somatostatinergic_system_in_rat_hippocampus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-3940(94)90701-3 DB - PRIME DP - Unbound Medicine ER -