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MHC class II and ICAM-1 expression and lymphocyte subsets in transbronchial biopsies from lung transplant recipients.
Transplantation. 1994 Jun 27; 57(12):1762-6.T

Abstract

The expression of MHC class II antigens and ICAM-1 and the composition of lymphocyte infiltrates have been studied in frozen sections of transbronchial biopsies from lung transplant recipients. First, biopsies obtained from patients who showed acute rejection, OB, and normal features were compared. Second, we compared first-year biopsies from patients developing OB and patients with a good clinical outcome. HLA-DR was widely expressed on epithelia and vascular endothelium. Increased vascular HLA-DP expression was found in OB biopsies. In OB patients there was a significantly increased frequency of bronchial HLA-DP and vascular HLA-DQ expression. Expression of ICAM-1 by bronchial and bronchiolar basal cells, a phenomenon not reported previously in humans, was seen in a small number of biopsies. CD8 predominant lymphocytic infiltrates were present in all groups and were increased in OB biopsies and OB patients. Increased numbers of CD4-positive cells were found in rejection and OB when compared with normal biopsies. These findings support an immunological basis for the development of OB.

Authors+Show Affiliations

University Department of Pathology, Royal Victoria Infirmary, Newcastle-upon-Tyne, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7912458

Citation

Milne, D S., et al. "MHC Class II and ICAM-1 Expression and Lymphocyte Subsets in Transbronchial Biopsies From Lung Transplant Recipients." Transplantation, vol. 57, no. 12, 1994, pp. 1762-6.
Milne DS, Gascoigne AD, Wilkes J, et al. MHC class II and ICAM-1 expression and lymphocyte subsets in transbronchial biopsies from lung transplant recipients. Transplantation. 1994;57(12):1762-6.
Milne, D. S., Gascoigne, A. D., Wilkes, J., Sviland, L., Ashcroft, T., Malcolm, A. J., & Corris, P. A. (1994). MHC class II and ICAM-1 expression and lymphocyte subsets in transbronchial biopsies from lung transplant recipients. Transplantation, 57(12), 1762-6.
Milne DS, et al. MHC Class II and ICAM-1 Expression and Lymphocyte Subsets in Transbronchial Biopsies From Lung Transplant Recipients. Transplantation. 1994 Jun 27;57(12):1762-6. PubMed PMID: 7912458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MHC class II and ICAM-1 expression and lymphocyte subsets in transbronchial biopsies from lung transplant recipients. AU - Milne,D S, AU - Gascoigne,A D, AU - Wilkes,J, AU - Sviland,L, AU - Ashcroft,T, AU - Malcolm,A J, AU - Corris,P A, PY - 1994/6/27/pubmed PY - 1994/6/27/medline PY - 1994/6/27/entrez SP - 1762 EP - 6 JF - Transplantation JO - Transplantation VL - 57 IS - 12 N2 - The expression of MHC class II antigens and ICAM-1 and the composition of lymphocyte infiltrates have been studied in frozen sections of transbronchial biopsies from lung transplant recipients. First, biopsies obtained from patients who showed acute rejection, OB, and normal features were compared. Second, we compared first-year biopsies from patients developing OB and patients with a good clinical outcome. HLA-DR was widely expressed on epithelia and vascular endothelium. Increased vascular HLA-DP expression was found in OB biopsies. In OB patients there was a significantly increased frequency of bronchial HLA-DP and vascular HLA-DQ expression. Expression of ICAM-1 by bronchial and bronchiolar basal cells, a phenomenon not reported previously in humans, was seen in a small number of biopsies. CD8 predominant lymphocytic infiltrates were present in all groups and were increased in OB biopsies and OB patients. Increased numbers of CD4-positive cells were found in rejection and OB when compared with normal biopsies. These findings support an immunological basis for the development of OB. SN - 0041-1337 UR - https://www.unboundmedicine.com/medline/citation/7912458/MHC_class_II_and_ICAM_1_expression_and_lymphocyte_subsets_in_transbronchial_biopsies_from_lung_transplant_recipients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7912458.ui DB - PRIME DP - Unbound Medicine ER -