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Haemodynamic effects of long-term oral labetalol.
Br J Clin Pharmacol. 1976 Aug; 3(4 Suppl 3):733-6.BJ

Abstract

1 The haemodynamic effects of labetalol have been studied in 11 hypertensive patients after 1 month of oral administration at a fixed dose of 800 mg/d. 2 Heart rate blood pressure and cardiac output were measured at rest and at two levels of exercise. 3 Labetalol significantly reduced heart rate and blood pressure at rest and after exercise but cardiac output remained unchanged. 4 The results suggest that labetalol is an effective anti-hypertensive agent acting by competitive adrenoreceptor blockade.

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Authors

Edwards RC
No affiliation info available
Raftery EB
No affiliation info available

MeSH

Administration, OralAdultBlood PressureCardiac OutputClinical Trials as TopicDrug Administration ScheduleEthanolaminesFemaleHeart RateHemodynamicsHumansHypertensionLabetalolMaleMiddle AgedVascular Resistance

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

791328

Citation

Edwards, R C., and E B. Raftery. "Haemodynamic Effects of Long-term Oral Labetalol." British Journal of Clinical Pharmacology, vol. 3, no. 4 Suppl 3, 1976, pp. 733-6.
Edwards RC, Raftery EB. Haemodynamic effects of long-term oral labetalol. Br J Clin Pharmacol. 1976;3(4 Suppl 3):733-6.
Edwards, R. C., & Raftery, E. B. (1976). Haemodynamic effects of long-term oral labetalol. British Journal of Clinical Pharmacology, 3(4 Suppl 3), 733-6.
Edwards RC, Raftery EB. Haemodynamic Effects of Long-term Oral Labetalol. Br J Clin Pharmacol. 1976;3(4 Suppl 3):733-6. PubMed PMID: 791328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemodynamic effects of long-term oral labetalol. AU - Edwards,R C, AU - Raftery,E B, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 733 EP - 6 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 3 IS - 4 Suppl 3 N2 - 1 The haemodynamic effects of labetalol have been studied in 11 hypertensive patients after 1 month of oral administration at a fixed dose of 800 mg/d. 2 Heart rate blood pressure and cardiac output were measured at rest and at two levels of exercise. 3 Labetalol significantly reduced heart rate and blood pressure at rest and after exercise but cardiac output remained unchanged. 4 The results suggest that labetalol is an effective anti-hypertensive agent acting by competitive adrenoreceptor blockade. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/791328/Haemodynamic_effects_of_long_term_oral_labetalol_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1976&volume=3&issue=4 Suppl 3&spage=733 DB - PRIME DP - Unbound Medicine ER -