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Controlled comparison of labetalol and propranolol in the management of severe hypertension.
Br J Clin Pharmacol. 1976 Aug; 3(4 Suppl 3):777-82.BJ

Abstract

1 Labetalol, a new hypotensive drug combining alpha- and beta-adrenoreceptor antagonist properties, has been compared with propranolol in the treatment of severe hypertension (blood pressure 190/115-249/139 mmHg) in a double-blind trial lasting 14 weeks. Additional diuretic therapy was given to both groups of patients. 2 Both drugs caused an effective reduction in blood pressure, bbut labetalol caused a greater fall in pressure in the standing position and after exercise. Two groups of nine patients have each completed the trial so far. Group average pressures for the last 3 weeks of treatment were: for labetalol 137/87 supine, 121/84 standing, and 117/78 mmHg after exercise; and for propranolol, 138/87 supine, 132/93 standing, and 133/94 mmHg after exercise. 3 Group average heart rates were lower in all three positions for those patients treated with propranolol compared with labetalol. 4 The average final dose ratio for labetalol: propranolol was 1.44:1 (w/w). 5 Labetalol initially induced a number of side-effects, predominantly related to alpha-adrenoreceptor blockade, which disappeared by the end of the trial. 6 Labetalol, in conjunction with diuretic therapy, was at least as effective as propranolol in lowering blood pressure in patients with severe hypertension.

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Authors

Pugsley DJ
No affiliation info available
Armstrong BK
No affiliation info available
Nassim MA
No affiliation info available
Beilin LJ
No affiliation info available

MeSH

AdultAntibodies, AntinuclearAspartate AminotransferasesBlood PressureClinical Trials as TopicDiureticsDose-Response Relationship, DrugDrug EvaluationDrug Therapy, CombinationEthanolaminesFemaleHumansHypertensionLabetalolMaleMiddle AgedPropranololPulseTime Factors

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

791331

Citation

Pugsley, D J., et al. "Controlled Comparison of Labetalol and Propranolol in the Management of Severe Hypertension." British Journal of Clinical Pharmacology, vol. 3, no. 4 Suppl 3, 1976, pp. 777-82.
Pugsley DJ, Armstrong BK, Nassim MA, et al. Controlled comparison of labetalol and propranolol in the management of severe hypertension. Br J Clin Pharmacol. 1976;3(4 Suppl 3):777-82.
Pugsley, D. J., Armstrong, B. K., Nassim, M. A., & Beilin, L. J. (1976). Controlled comparison of labetalol and propranolol in the management of severe hypertension. British Journal of Clinical Pharmacology, 3(4 Suppl 3), 777-82.
Pugsley DJ, et al. Controlled Comparison of Labetalol and Propranolol in the Management of Severe Hypertension. Br J Clin Pharmacol. 1976;3(4 Suppl 3):777-82. PubMed PMID: 791331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled comparison of labetalol and propranolol in the management of severe hypertension. AU - Pugsley,D J, AU - Armstrong,B K, AU - Nassim,M A, AU - Beilin,L J, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 777 EP - 82 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 3 IS - 4 Suppl 3 N2 - 1 Labetalol, a new hypotensive drug combining alpha- and beta-adrenoreceptor antagonist properties, has been compared with propranolol in the treatment of severe hypertension (blood pressure 190/115-249/139 mmHg) in a double-blind trial lasting 14 weeks. Additional diuretic therapy was given to both groups of patients. 2 Both drugs caused an effective reduction in blood pressure, bbut labetalol caused a greater fall in pressure in the standing position and after exercise. Two groups of nine patients have each completed the trial so far. Group average pressures for the last 3 weeks of treatment were: for labetalol 137/87 supine, 121/84 standing, and 117/78 mmHg after exercise; and for propranolol, 138/87 supine, 132/93 standing, and 133/94 mmHg after exercise. 3 Group average heart rates were lower in all three positions for those patients treated with propranolol compared with labetalol. 4 The average final dose ratio for labetalol: propranolol was 1.44:1 (w/w). 5 Labetalol initially induced a number of side-effects, predominantly related to alpha-adrenoreceptor blockade, which disappeared by the end of the trial. 6 Labetalol, in conjunction with diuretic therapy, was at least as effective as propranolol in lowering blood pressure in patients with severe hypertension. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/791331/Controlled_comparison_of_labetalol_and_propranolol_in_the_management_of_severe_hypertension_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1976&volume=3&issue=4 Suppl 3&spage=777 DB - PRIME DP - Unbound Medicine ER -