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The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.
Genomics. 1994 May 15; 21(2):403-8.G

Abstract

Monocyte chemotactic proteins (MCPs) are chemokines involved in macrophage recruitment during inflammation and cancer. A full-size MCP-3 cDNA was used to isolate the functional human MCP-3 gene. Based on restriction analysis, subclones were selected and the MCP-3 gene sequence was completed. In addition to a dense region with direct and inverted repeats and palindromic sequences, a double microsatellite (CA)n-(GA)n' was found at the 5'-end of the MCP-3 gene, and an RFLP was detected. The gene was regionally mapped by fluorescence in situ hybridization to human chromosome 17, subbands q11.2-q12. This site contains the MCP-subset of C-C chemokines and can be distinguished from the syntenic MIP-1 alpha locus. SCYA7 was assigned as the locus symbol of the MCP-3 gene. Double-labeling experiments confirmed the regional assignment of the MCP-3 gene close to the ERBB2 locus on human chromosome 17.

Authors+Show Affiliations

Rega Institute, University of Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7916328

Citation

Opdenakker, G, et al. "The Human MCP-3 Gene (SCYA7): Cloning, Sequence Analysis, and Assignment to the C-C Chemokine Gene Cluster On Chromosome 17q11.2-q12." Genomics, vol. 21, no. 2, 1994, pp. 403-8.
Opdenakker G, Fiten P, Nys G, et al. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. Genomics. 1994;21(2):403-8.
Opdenakker, G., Fiten, P., Nys, G., Froyen, G., Van Roy, N., Speleman, F., Laureys, G., & Van Damme, J. (1994). The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. Genomics, 21(2), 403-8.
Opdenakker G, et al. The Human MCP-3 Gene (SCYA7): Cloning, Sequence Analysis, and Assignment to the C-C Chemokine Gene Cluster On Chromosome 17q11.2-q12. Genomics. 1994 May 15;21(2):403-8. PubMed PMID: 7916328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. AU - Opdenakker,G, AU - Fiten,P, AU - Nys,G, AU - Froyen,G, AU - Van Roy,N, AU - Speleman,F, AU - Laureys,G, AU - Van Damme,J, PY - 1994/5/15/pubmed PY - 1994/5/15/medline PY - 1994/5/15/entrez SP - 403 EP - 8 JF - Genomics JO - Genomics VL - 21 IS - 2 N2 - Monocyte chemotactic proteins (MCPs) are chemokines involved in macrophage recruitment during inflammation and cancer. A full-size MCP-3 cDNA was used to isolate the functional human MCP-3 gene. Based on restriction analysis, subclones were selected and the MCP-3 gene sequence was completed. In addition to a dense region with direct and inverted repeats and palindromic sequences, a double microsatellite (CA)n-(GA)n' was found at the 5'-end of the MCP-3 gene, and an RFLP was detected. The gene was regionally mapped by fluorescence in situ hybridization to human chromosome 17, subbands q11.2-q12. This site contains the MCP-subset of C-C chemokines and can be distinguished from the syntenic MIP-1 alpha locus. SCYA7 was assigned as the locus symbol of the MCP-3 gene. Double-labeling experiments confirmed the regional assignment of the MCP-3 gene close to the ERBB2 locus on human chromosome 17. SN - 0888-7543 UR - https://www.unboundmedicine.com/medline/citation/7916328/The_human_MCP_3_gene__SCYA7_:_cloning_sequence_analysis_and_assignment_to_the_C_C_chemokine_gene_cluster_on_chromosome_17q11_2_q12_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0888-7543(84)71283-3 DB - PRIME DP - Unbound Medicine ER -