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Intrauterine device use and risk of endometrial cancer.
Br J Cancer 1994; 70(4):672-3BJ

Abstract

The relationship between intrauterine device (IUD) use and risk of endometrial cancer has been analysed in a case-control study conducted in Italy between 1983 and 1992, including 453 patients with histologically confirmed endometrial cancer and 1,451 controls admitted for acute, non-gynaecological, non-hormonal, non-neoplastic conditions to the same network of hospitals where cases had been identified. Two (0.4%) cases versus 36 (2.3%) controls reported ever using an IUD. The corresponding multivariate relative risk was 0.4 (95% CI 0.1-1.0). The results of this study and the few published available epidemiological data suggest a protective role of IUD use on endometrial carcinogenesis, but potential selective mechanisms for IUD utilisation (indication bias) should be carefully considered in the interpretation.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7917915

Citation

Parazzini, F, et al. "Intrauterine Device Use and Risk of Endometrial Cancer." British Journal of Cancer, vol. 70, no. 4, 1994, pp. 672-3.
Parazzini F, La Vecchia C, Moroni S. Intrauterine device use and risk of endometrial cancer. Br J Cancer. 1994;70(4):672-3.
Parazzini, F., La Vecchia, C., & Moroni, S. (1994). Intrauterine device use and risk of endometrial cancer. British Journal of Cancer, 70(4), pp. 672-3.
Parazzini F, La Vecchia C, Moroni S. Intrauterine Device Use and Risk of Endometrial Cancer. Br J Cancer. 1994;70(4):672-3. PubMed PMID: 7917915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrauterine device use and risk of endometrial cancer. AU - Parazzini,F, AU - La Vecchia,C, AU - Moroni,S, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez KW - Bias KW - Biology KW - Body Weight KW - Cancer KW - Case Control Studies KW - Contraception KW - Contraceptive Methods KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Endometrial Cancer KW - Error Sources KW - Europe KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Hormone Replacement Therapy KW - Italy KW - Iud KW - Measurement KW - Mediterranean Countries KW - Neoplasms KW - Nulliparity KW - Parity KW - Physiology KW - Population KW - Population Dynamics KW - Research Report KW - Southern Europe KW - Studies KW - Treatment SP - 672 EP - 3 JF - British journal of cancer JO - Br. J. Cancer VL - 70 IS - 4 N2 - The relationship between intrauterine device (IUD) use and risk of endometrial cancer has been analysed in a case-control study conducted in Italy between 1983 and 1992, including 453 patients with histologically confirmed endometrial cancer and 1,451 controls admitted for acute, non-gynaecological, non-hormonal, non-neoplastic conditions to the same network of hospitals where cases had been identified. Two (0.4%) cases versus 36 (2.3%) controls reported ever using an IUD. The corresponding multivariate relative risk was 0.4 (95% CI 0.1-1.0). The results of this study and the few published available epidemiological data suggest a protective role of IUD use on endometrial carcinogenesis, but potential selective mechanisms for IUD utilisation (indication bias) should be carefully considered in the interpretation. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/7917915/Intrauterine_device_use_and_risk_of_endometrial_cancer_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7917915/ DB - PRIME DP - Unbound Medicine ER -