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Parkinson's disease: making the diagnosis, selecting drug therapies.
Geriatrics. 1994 Oct; 49(10):14-6, 20-3.G

Abstract

Parkinson's disease is a progressive neurodegenerative condition of unknown cause and with no known cure. The diagnosis is based on clinical findings of rest tremor, muscle rigidity, bradykinesia, and gait instability. Over 40% of patients develop a dementia syndrome that is largely distinct from Alzheimer's disease. Depression is common, also occurring in more than 40% of patients with PD. Careful evaluation in necessary to help distinguish Parkinson's disease from secondary causes of parkinsonism. Carbidopa/levodopa, dopamine agonists, and monoamine oxidase type B inhibitors are the mainstays of treatment. Anticholinergics and other agents may also be useful. Pharmacologic treatment must be carefully titrated to control symptoms and to avoid side effects. In advanced disease, dose-related dyskinesias, end-of-dose wearing-off effect, and unpredictable sudden motor fluctuations become very disabling and difficult to manage.

Authors+Show Affiliations

UCLA School of Medicine.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7926845

Citation

Scharre, D W., and M E. Mahler. "Parkinson's Disease: Making the Diagnosis, Selecting Drug Therapies." Geriatrics, vol. 49, no. 10, 1994, pp. 14-6, 20-3.
Scharre DW, Mahler ME. Parkinson's disease: making the diagnosis, selecting drug therapies. Geriatrics. 1994;49(10):14-6, 20-3.
Scharre, D. W., & Mahler, M. E. (1994). Parkinson's disease: making the diagnosis, selecting drug therapies. Geriatrics, 49(10), 14-6, 20-3.
Scharre DW, Mahler ME. Parkinson's Disease: Making the Diagnosis, Selecting Drug Therapies. Geriatrics. 1994;49(10):14-6, 20-3. PubMed PMID: 7926845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease: making the diagnosis, selecting drug therapies. AU - Scharre,D W, AU - Mahler,M E, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 14-6, 20-3 JF - Geriatrics JO - Geriatrics VL - 49 IS - 10 N2 - Parkinson's disease is a progressive neurodegenerative condition of unknown cause and with no known cure. The diagnosis is based on clinical findings of rest tremor, muscle rigidity, bradykinesia, and gait instability. Over 40% of patients develop a dementia syndrome that is largely distinct from Alzheimer's disease. Depression is common, also occurring in more than 40% of patients with PD. Careful evaluation in necessary to help distinguish Parkinson's disease from secondary causes of parkinsonism. Carbidopa/levodopa, dopamine agonists, and monoamine oxidase type B inhibitors are the mainstays of treatment. Anticholinergics and other agents may also be useful. Pharmacologic treatment must be carefully titrated to control symptoms and to avoid side effects. In advanced disease, dose-related dyskinesias, end-of-dose wearing-off effect, and unpredictable sudden motor fluctuations become very disabling and difficult to manage. SN - 0016-867X UR - https://www.unboundmedicine.com/medline/citation/7926845/Parkinson's_disease:_making_the_diagnosis_selecting_drug_therapies_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -