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Comparative efficacy and safety of cefprozil and amoxycillin/clavulanate in the treatment of acute otitis media in children.
J Antimicrob Chemother. 1994 Jun; 33(6):1209-18.JA

Abstract

Cefprozil is a new oral cephalosporin with activity against the most common pathogens isolated in acute otitis media. This randomized study enrolled 361 patients (mean age 29 months). Physical examination and culture via tympanocentesis were required less than 48 h before therapy. One hundred and ninety-one patients were evaluable for clinical efficacy; 99 received cefprozil (20 mg/kg/day bd) and 92 received amoxycillin/clavulanate (13.3 mg/kg/day tid). Duration of treatment was 7-9 days for 81 patients, 10 days for 105 patients and 11-16 days for five patients. The treatment groups were comparable with respect to demographics, severity of infection and number of previous episodes. Clinical evaluations of efficacy were based on physical examination including otoscopy within a 14 day period after therapy. Satisfactory clinical responses were achieved in 84% of cefprozil-treated patients and 87% of amoxycillin/clavulanate-treated patients. Pathogens most commonly isolated included Haemophilus influenzae (33%) and Streptococcus pneumoniae (22%). All 361 patients were evaluable for safety. Adverse clinical events were reported in 13% (24) of cefprozil-treated patients and 20% (36) of amoxycillin/clavulanate-treated patients. Cefprozil, administered twice a day, is comparable to a regimen of amoxycillin/clavulanate three times a day in the treatment of acute otitis media in children.

Authors+Show Affiliations

Hôpital Bichat Claude Bernard, O.R.L. et Chirurgie Faciale, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7928814

Citation

Gehanno, P, et al. "Comparative Efficacy and Safety of Cefprozil and Amoxycillin/clavulanate in the Treatment of Acute Otitis Media in Children." The Journal of Antimicrobial Chemotherapy, vol. 33, no. 6, 1994, pp. 1209-18.
Gehanno P, Berche P, Boucot I, et al. Comparative efficacy and safety of cefprozil and amoxycillin/clavulanate in the treatment of acute otitis media in children. J Antimicrob Chemother. 1994;33(6):1209-18.
Gehanno, P., Berche, P., Boucot, I., Lambert-Zechovsky, N., Bingen, E., Gres, J. J., & Rollin, C. (1994). Comparative efficacy and safety of cefprozil and amoxycillin/clavulanate in the treatment of acute otitis media in children. The Journal of Antimicrobial Chemotherapy, 33(6), 1209-18.
Gehanno P, et al. Comparative Efficacy and Safety of Cefprozil and Amoxycillin/clavulanate in the Treatment of Acute Otitis Media in Children. J Antimicrob Chemother. 1994;33(6):1209-18. PubMed PMID: 7928814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative efficacy and safety of cefprozil and amoxycillin/clavulanate in the treatment of acute otitis media in children. AU - Gehanno,P, AU - Berche,P, AU - Boucot,I, AU - Lambert-Zechovsky,N, AU - Bingen,E, AU - Gres,J J, AU - Rollin,C, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 1209 EP - 18 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 33 IS - 6 N2 - Cefprozil is a new oral cephalosporin with activity against the most common pathogens isolated in acute otitis media. This randomized study enrolled 361 patients (mean age 29 months). Physical examination and culture via tympanocentesis were required less than 48 h before therapy. One hundred and ninety-one patients were evaluable for clinical efficacy; 99 received cefprozil (20 mg/kg/day bd) and 92 received amoxycillin/clavulanate (13.3 mg/kg/day tid). Duration of treatment was 7-9 days for 81 patients, 10 days for 105 patients and 11-16 days for five patients. The treatment groups were comparable with respect to demographics, severity of infection and number of previous episodes. Clinical evaluations of efficacy were based on physical examination including otoscopy within a 14 day period after therapy. Satisfactory clinical responses were achieved in 84% of cefprozil-treated patients and 87% of amoxycillin/clavulanate-treated patients. Pathogens most commonly isolated included Haemophilus influenzae (33%) and Streptococcus pneumoniae (22%). All 361 patients were evaluable for safety. Adverse clinical events were reported in 13% (24) of cefprozil-treated patients and 20% (36) of amoxycillin/clavulanate-treated patients. Cefprozil, administered twice a day, is comparable to a regimen of amoxycillin/clavulanate three times a day in the treatment of acute otitis media in children. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/7928814/Comparative_efficacy_and_safety_of_cefprozil_and_amoxycillin/clavulanate_in_the_treatment_of_acute_otitis_media_in_children_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/33.6.1209 DB - PRIME DP - Unbound Medicine ER -