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Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. Tonawanda/Williamsville Pediatrics.
J Infect Dis. 1994 Oct; 170(4):862-6.JI

Abstract

The relationship between nasopharyngeal colonization with nontypeable H. influenzae and recurrent otitis media was assessed in 157 children followed prospectively from birth through 12 months of age. Forty-nine (31%) became colonized. Nasopharyngeal secretory IgA (sIgA) reactive with the P6 outer membrane protein was detected in all colonized children. Reduction or elimination of the organism was associated with a better mucosal immune response (560 +/- 864 units/ng/mL of sIgA) than was persistence in the nasopharynx (121 +/- 81; P = .04). Forty colonized children (82%) and 61 noncolonized children (56%) developed otitis media (P = .004); colonized children were four times more likely to be classified as otitis prone (P = .003). The frequency of otitis media episodes was directly related to the frequency of colonization (r = .42, P < .01). These results demonstrate a strong relationship between nasopharyngeal colonization patterns and otitis media. The mucosal immune response may be important in elimination of potential pathogens from the respiratory tract.

Authors+Show Affiliations

Department of Otolaryngology, Sapporo Medical College, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7930728

Citation

Harabuchi, Y, et al. "Nasopharyngeal Colonization With Nontypeable Haemophilus Influenzae and Recurrent Otitis Media. Tonawanda/Williamsville Pediatrics." The Journal of Infectious Diseases, vol. 170, no. 4, 1994, pp. 862-6.
Harabuchi Y, Faden H, Yamanaka N, et al. Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. Tonawanda/Williamsville Pediatrics. J Infect Dis. 1994;170(4):862-6.
Harabuchi, Y., Faden, H., Yamanaka, N., Duffy, L., Wolf, J., & Krystofik, D. (1994). Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. Tonawanda/Williamsville Pediatrics. The Journal of Infectious Diseases, 170(4), 862-6.
Harabuchi Y, et al. Nasopharyngeal Colonization With Nontypeable Haemophilus Influenzae and Recurrent Otitis Media. Tonawanda/Williamsville Pediatrics. J Infect Dis. 1994;170(4):862-6. PubMed PMID: 7930728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. Tonawanda/Williamsville Pediatrics. AU - Harabuchi,Y, AU - Faden,H, AU - Yamanaka,N, AU - Duffy,L, AU - Wolf,J, AU - Krystofik,D, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 862 EP - 6 JF - The Journal of infectious diseases JO - J Infect Dis VL - 170 IS - 4 N2 - The relationship between nasopharyngeal colonization with nontypeable H. influenzae and recurrent otitis media was assessed in 157 children followed prospectively from birth through 12 months of age. Forty-nine (31%) became colonized. Nasopharyngeal secretory IgA (sIgA) reactive with the P6 outer membrane protein was detected in all colonized children. Reduction or elimination of the organism was associated with a better mucosal immune response (560 +/- 864 units/ng/mL of sIgA) than was persistence in the nasopharynx (121 +/- 81; P = .04). Forty colonized children (82%) and 61 noncolonized children (56%) developed otitis media (P = .004); colonized children were four times more likely to be classified as otitis prone (P = .003). The frequency of otitis media episodes was directly related to the frequency of colonization (r = .42, P < .01). These results demonstrate a strong relationship between nasopharyngeal colonization patterns and otitis media. The mucosal immune response may be important in elimination of potential pathogens from the respiratory tract. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/7930728/Nasopharyngeal_colonization_with_nontypeable_Haemophilus_influenzae_and_recurrent_otitis_media__Tonawanda/Williamsville_Pediatrics_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/170.4.862 DB - PRIME DP - Unbound Medicine ER -