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alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats.
J Nutr. 1994 Oct; 124(10):1898-906.JN

Abstract

Rats were fed purified diets containing 10% fat with constant (n-6):(n-3) polyunsaturated fatty acids [(n-6):(n-3); 2.3-2.6] and polyunsaturated:saturated fatty acids (1) ratios. This was obtained with alpha-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid added at 1 g/100 g diet. Eicosapentaenoic acid and docosahexaenoic acid were added as the ethyl esters. The concentration of plasma cholesterol in rats fed docosahexaenoic acid was significantly lower than in those fed alpha-linolenic acid. The concentration of plasma triglyceride was significantly lower in rats fed eicosapentaenoic acid than in those fed docosahexaenoic acid. Docosahexaenoic acid significantly reduced hepatic cholesterol compared with alpha-linolenic acid and eicosapentaenoic acid. Both eicosapentaenoic acid and docosahexaenoic acid decreased hepatic triglyceride compared with alpha-linolenic acid, but this effect was more pronounced in the docosahexaenoic acid group. There was no significant difference in fecal excretion of neutral and acidic steroids and apparent fat absorption. In rats fed docosahexaenoic acid, the proportion of arachidonic acid in liver microsomal phosphatidylcholine was lower than in those fed eicosapentaenoic acid. The same tendency was observed in plasma, platelet and aortic phosphatidylcholine and liver microsomal phosphatidylethanolamine and phosphatidylinositol. Dietary docosahexaenoic acid, but not eicosapentaenoic acid, significantly decreased aortic production of prostacyclin compared to alpha-linolenic acid, whereas platelet aggregation by collagen was not affected by the difference in dietary (n-3) polyunsaturated fatty acids.

Authors+Show Affiliations

Laboratory of Nutrition Chemistry, Kyushu University, School of Agriculture, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7931698

Citation

Ikeda, I, et al. "Alpha-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids Affect Lipid Metabolism Differently in Rats." The Journal of Nutrition, vol. 124, no. 10, 1994, pp. 1898-906.
Ikeda I, Wakamatsu K, Inayoshi A, et al. Alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. J Nutr. 1994;124(10):1898-906.
Ikeda, I., Wakamatsu, K., Inayoshi, A., Imaizumi, K., Sugano, M., & Yazawa, K. (1994). Alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. The Journal of Nutrition, 124(10), 1898-906.
Ikeda I, et al. Alpha-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids Affect Lipid Metabolism Differently in Rats. J Nutr. 1994;124(10):1898-906. PubMed PMID: 7931698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. AU - Ikeda,I, AU - Wakamatsu,K, AU - Inayoshi,A, AU - Imaizumi,K, AU - Sugano,M, AU - Yazawa,K, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 1898 EP - 906 JF - The Journal of nutrition JO - J Nutr VL - 124 IS - 10 N2 - Rats were fed purified diets containing 10% fat with constant (n-6):(n-3) polyunsaturated fatty acids [(n-6):(n-3); 2.3-2.6] and polyunsaturated:saturated fatty acids (1) ratios. This was obtained with alpha-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid added at 1 g/100 g diet. Eicosapentaenoic acid and docosahexaenoic acid were added as the ethyl esters. The concentration of plasma cholesterol in rats fed docosahexaenoic acid was significantly lower than in those fed alpha-linolenic acid. The concentration of plasma triglyceride was significantly lower in rats fed eicosapentaenoic acid than in those fed docosahexaenoic acid. Docosahexaenoic acid significantly reduced hepatic cholesterol compared with alpha-linolenic acid and eicosapentaenoic acid. Both eicosapentaenoic acid and docosahexaenoic acid decreased hepatic triglyceride compared with alpha-linolenic acid, but this effect was more pronounced in the docosahexaenoic acid group. There was no significant difference in fecal excretion of neutral and acidic steroids and apparent fat absorption. In rats fed docosahexaenoic acid, the proportion of arachidonic acid in liver microsomal phosphatidylcholine was lower than in those fed eicosapentaenoic acid. The same tendency was observed in plasma, platelet and aortic phosphatidylcholine and liver microsomal phosphatidylethanolamine and phosphatidylinositol. Dietary docosahexaenoic acid, but not eicosapentaenoic acid, significantly decreased aortic production of prostacyclin compared to alpha-linolenic acid, whereas platelet aggregation by collagen was not affected by the difference in dietary (n-3) polyunsaturated fatty acids. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/7931698/alpha_Linolenic_eicosapentaenoic_and_docosahexaenoic_acids_affect_lipid_metabolism_differently_in_rats_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/124.10.1898 DB - PRIME DP - Unbound Medicine ER -