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A pilot project to assess the association of anticholinergic symptoms with anticholinergic serum levels in the elderly.
Pharmacotherapy. 1994 Jul-Aug; 14(4):482-7.P

Abstract

STUDY OBJECTIVE

To evaluate whether serum anticholinergic drug activity would be a useful clinical tool in helping to predict anticholinergic toxicity.

DESIGN

A prospective study that included a retrospective chart review.

SETTING

Two nursing home facilities.

SUBJECTS

Thirty-one elderly volunteers between ages 69 and 98 years.

INTERVENTION

Each subject completed a two-part interview. First, anticholinergic symptoms were evaluated and then cognitive function was assessed by three neuropsychiatric tests. Blood (10 ml) was collected to measure anticholinergic activity.

MEASUREMENTS AND MAIN RESULTS

Eight subjects had detectable serum anticholinergic activity and scored higher on the Symbol Digit Modalities test than those with no detectable activity. No statistical difference was seen between the groups with respect to symptoms or results of the Mini-Mental and Auditory-Verbal Learning tests.

CONCLUSION

The clinical usefulness of serum anticholinergic activity as a predictor for anticholinergic toxicity was not established under the experimental design of this study.

Authors+Show Affiliations

College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7937286

Citation

Remillard, A J.. "A Pilot Project to Assess the Association of Anticholinergic Symptoms With Anticholinergic Serum Levels in the Elderly." Pharmacotherapy, vol. 14, no. 4, 1994, pp. 482-7.
Remillard AJ. A pilot project to assess the association of anticholinergic symptoms with anticholinergic serum levels in the elderly. Pharmacotherapy. 1994;14(4):482-7.
Remillard, A. J. (1994). A pilot project to assess the association of anticholinergic symptoms with anticholinergic serum levels in the elderly. Pharmacotherapy, 14(4), 482-7.
Remillard AJ. A Pilot Project to Assess the Association of Anticholinergic Symptoms With Anticholinergic Serum Levels in the Elderly. Pharmacotherapy. 1994 Jul-Aug;14(4):482-7. PubMed PMID: 7937286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot project to assess the association of anticholinergic symptoms with anticholinergic serum levels in the elderly. A1 - Remillard,A J, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 482 EP - 7 JF - Pharmacotherapy JO - Pharmacotherapy VL - 14 IS - 4 N2 - STUDY OBJECTIVE: To evaluate whether serum anticholinergic drug activity would be a useful clinical tool in helping to predict anticholinergic toxicity. DESIGN: A prospective study that included a retrospective chart review. SETTING: Two nursing home facilities. SUBJECTS: Thirty-one elderly volunteers between ages 69 and 98 years. INTERVENTION: Each subject completed a two-part interview. First, anticholinergic symptoms were evaluated and then cognitive function was assessed by three neuropsychiatric tests. Blood (10 ml) was collected to measure anticholinergic activity. MEASUREMENTS AND MAIN RESULTS: Eight subjects had detectable serum anticholinergic activity and scored higher on the Symbol Digit Modalities test than those with no detectable activity. No statistical difference was seen between the groups with respect to symptoms or results of the Mini-Mental and Auditory-Verbal Learning tests. CONCLUSION: The clinical usefulness of serum anticholinergic activity as a predictor for anticholinergic toxicity was not established under the experimental design of this study. SN - 0277-0008 UR - https://www.unboundmedicine.com/medline/citation/7937286/A_pilot_project_to_assess_the_association_of_anticholinergic_symptoms_with_anticholinergic_serum_levels_in_the_elderly_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0277-0008&date=1994&volume=14&issue=4&spage=482 DB - PRIME DP - Unbound Medicine ER -