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Vitamin E deficiency increases serum thromboxane A2, platelet arachidonate and lipid peroxidation in male Sprague-Dawley rats.

Abstract

This study was designed to determine whether dietary linoleate and all-rac-alpha-tocopheryl acetate (vitamin E) interact to affect serum thromboxane A2 (TXA2) and prostacyclin (PGI2) status and therefore, thrombogenic potential. 6 groups of 12 weanling male Sprague-Dawley rats were fed semipurified diets containing 11 or 18% of energy from linoleate and 0, 100 or 5000 mg vitamin E/kg diet for 10 weeks. Platelet and serum alpha-tocopherol concentrations increased logarithmically with increasing dietary vitamin E. Serum TXA2, measured as TXB2, platelet arachidonate and thiobarbituric acid reactive substances were significantly greater in the vitamin E deficient groups than in groups receiving vitamin E (p < 0.05). Serum PGI2 levels, determined as 6-keto-PGF1 alpha, were not affected by diets. No interaction was found between dietary linoleate and vitamin E. However, vitamin E supplementation produced significantly less serum TXB2 than did vitamin E deficient diets (p < 0.05). Vitamin E deficiency may be prothrombogenic by increasing platelet arachidonate, lipid peroxidation and serum TXA2 levels while vitamin E supplementation at levels used in this study may decrease such effects.

Authors+Show Affiliations

Department of Food Science and Human Nutrition, Ames, Iowa 50011-1120.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7938093

Citation

Chen, H W., et al. "Vitamin E Deficiency Increases Serum Thromboxane A2, Platelet Arachidonate and Lipid Peroxidation in Male Sprague-Dawley Rats." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 51, no. 1, 1994, pp. 11-7.
Chen HW, Hendrich S, Cook LR. Vitamin E deficiency increases serum thromboxane A2, platelet arachidonate and lipid peroxidation in male Sprague-Dawley rats. Prostaglandins Leukot Essent Fatty Acids. 1994;51(1):11-7.
Chen, H. W., Hendrich, S., & Cook, L. R. (1994). Vitamin E deficiency increases serum thromboxane A2, platelet arachidonate and lipid peroxidation in male Sprague-Dawley rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 51(1), 11-7.
Chen HW, Hendrich S, Cook LR. Vitamin E Deficiency Increases Serum Thromboxane A2, Platelet Arachidonate and Lipid Peroxidation in Male Sprague-Dawley Rats. Prostaglandins Leukot Essent Fatty Acids. 1994;51(1):11-7. PubMed PMID: 7938093.
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TY - JOUR T1 - Vitamin E deficiency increases serum thromboxane A2, platelet arachidonate and lipid peroxidation in male Sprague-Dawley rats. AU - Chen,H W, AU - Hendrich,S, AU - Cook,L R, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 11 EP - 7 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 51 IS - 1 N2 - This study was designed to determine whether dietary linoleate and all-rac-alpha-tocopheryl acetate (vitamin E) interact to affect serum thromboxane A2 (TXA2) and prostacyclin (PGI2) status and therefore, thrombogenic potential. 6 groups of 12 weanling male Sprague-Dawley rats were fed semipurified diets containing 11 or 18% of energy from linoleate and 0, 100 or 5000 mg vitamin E/kg diet for 10 weeks. Platelet and serum alpha-tocopherol concentrations increased logarithmically with increasing dietary vitamin E. Serum TXA2, measured as TXB2, platelet arachidonate and thiobarbituric acid reactive substances were significantly greater in the vitamin E deficient groups than in groups receiving vitamin E (p < 0.05). Serum PGI2 levels, determined as 6-keto-PGF1 alpha, were not affected by diets. No interaction was found between dietary linoleate and vitamin E. However, vitamin E supplementation produced significantly less serum TXB2 than did vitamin E deficient diets (p < 0.05). Vitamin E deficiency may be prothrombogenic by increasing platelet arachidonate, lipid peroxidation and serum TXA2 levels while vitamin E supplementation at levels used in this study may decrease such effects. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/7938093/Vitamin_E_deficiency_increases_serum_thromboxane_A2_platelet_arachidonate_and_lipid_peroxidation_in_male_Sprague_Dawley_rats_ L2 - https://antibodies.cancer.gov/detail/CPTC-AKT1-3 DB - PRIME DP - Unbound Medicine ER -