TY - JOUR T1 - Effect of highly selective vagotomy on gastric emptying, gastric acid secretion, and gastrin release: an early postoperative study in duodenal ulcer patients. AU - Lukasiewicz,S, AU - Jonderko,K, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 29 EP - 37 JF - The Tokai journal of experimental and clinical medicine JO - Tokai J Exp Clin Med VL - 18 IS - 1-2 N2 - In 12 duodenal ulcer patients, gastric emptying (GE) of a radiolabelled solid meal, gastric acid secretion, and gastrin release were examined before and during the early postoperative period (median 13.5 days) after a highly selective vagotomy (HSV). HSV significantly delayed GE; the median slope of GE curves (K) decreased from 11.86 to 6.52 min-1 x 10(-3) (p < 0.01). A significant inhibition of the late phase of GE was reflected by a diminution of the curve shape parameter (S) from a median of 1.41 to 0.98 (p < 0.02). A profound impairment of GE after HSV was found in 4 of 12 patients (33%). HSV resulted in a 49% decrease in the basal acid output (6.9 +/- 1.0 before to 3.5 +/- 1.0 mmol.h-1 after HSV, and a 56% reduction in the pentagastrin-stimulated gastric acid secretion (31.1 +/- 5.1 before vs 13.8 +/- 2.4 mmol.h-1 after HSV (p < 0.01). A significant increase in both the fasted serum gastrin (38.9 +/- 3.7 to 66.9 +/- 8.4 ng.l-1, p < 0.05) and the meal-stimulated gastrin release (AUC0-120: 7179 +/- 440 to 11158 +/- 1062 ng.l-1 min, p < 0.05) was observed after HSV. SN - 0385-0005 UR - https://www.unboundmedicine.com/medline/citation/7940604/Effect_of_highly_selective_vagotomy_on_gastric_emptying_gastric_acid_secretion_and_gastrin_release:_an_early_postoperative_study_in_duodenal_ulcer_patients_ L2 - http://www.medicalonline.jp/meteo_linkout.php?issn=0385-0005&amp;volume=18&amp;issue=1-2&amp;spage=29 DB - PRIME DP - Unbound Medicine ER -