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Alterations in upper gastrointestinal motility in Helicobacter pylori-positive nonulcer dyspepsia.
Am J Gastroenterol. 1994 Oct; 89(10):1797-800.AJ

Abstract

OBJECTIVE

To study the association between gastrointestinal motility and Helicobacter pylori (HP) among patients with nonulcer dyspepsia (NUD).

METHODS

We examined the gastric emptying and orocecal transit times (OCTT) in patients with NUD who were colonized with Helicobacter pylori (n = 27). NUD was defined as dyspeptic symptoms for at least 3 months in the absence of gastrointestinal pathology as seen on endoscopy and ultrasound. Subjects with diabetes mellitus, thyroid disorder, or abdominal surgery except appendectomy were excluded. The HP-negative patients with NUD (n = 38) served as controls. Solid phase gastric emptying was assessed by radionuclide scintigraphy. OCTT was determined by measuring exhaled breath hydrogen upon administration of lactulose.

RESULTS

The two groups were similar with respect to age, sex, race, and history of smoking. Gastric emptying (t1/2) was 64.96 +/- 3.61 min in the HP-negative and 61.0 +/- 6.59 in the HP-positive group (p = NS). The OCTT was 130.9 +/- 17.26 minutes in the HP-negative and 84.28 +/- 11.07 in the HP-positive group (p = 0.03). There was no difference in the prevalence of nonhydrogen producers between the two groups. There was no correlation between gastric emptying and OCTT (p > 0.05).

CONCLUSIONS

OCTT is faster among HP-positive patients with NUD than among HP-negative patients. However, gastric emptying is similar in the two groups.

Authors+Show Affiliations

Minocha A
Department of Medicine, University of Louisville, Kentucky.
Mokshagundam S
No affiliation info available
Gallo SH
No affiliation info available
Rahal PS
No affiliation info available

MeSH

Breath TestsDyspepsiaFemaleGastric EmptyingGastrointestinal MotilityGastrointestinal TransitHelicobacter InfectionsHelicobacter pyloriHumansLactuloseMaleMiddle Aged

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7942670

Citation

Minocha, A, et al. "Alterations in Upper Gastrointestinal Motility in Helicobacter Pylori-positive Nonulcer Dyspepsia." The American Journal of Gastroenterology, vol. 89, no. 10, 1994, pp. 1797-800.
Minocha A, Mokshagundam S, Gallo SH, et al. Alterations in upper gastrointestinal motility in Helicobacter pylori-positive nonulcer dyspepsia. Am J Gastroenterol. 1994;89(10):1797-800.
Minocha, A., Mokshagundam, S., Gallo, S. H., & Rahal, P. S. (1994). Alterations in upper gastrointestinal motility in Helicobacter pylori-positive nonulcer dyspepsia. The American Journal of Gastroenterology, 89(10), 1797-800.
Minocha A, et al. Alterations in Upper Gastrointestinal Motility in Helicobacter Pylori-positive Nonulcer Dyspepsia. Am J Gastroenterol. 1994;89(10):1797-800. PubMed PMID: 7942670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in upper gastrointestinal motility in Helicobacter pylori-positive nonulcer dyspepsia. AU - Minocha,A, AU - Mokshagundam,S, AU - Gallo,S H, AU - Rahal,P S, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 1797 EP - 800 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 89 IS - 10 N2 - OBJECTIVE: To study the association between gastrointestinal motility and Helicobacter pylori (HP) among patients with nonulcer dyspepsia (NUD). METHODS: We examined the gastric emptying and orocecal transit times (OCTT) in patients with NUD who were colonized with Helicobacter pylori (n = 27). NUD was defined as dyspeptic symptoms for at least 3 months in the absence of gastrointestinal pathology as seen on endoscopy and ultrasound. Subjects with diabetes mellitus, thyroid disorder, or abdominal surgery except appendectomy were excluded. The HP-negative patients with NUD (n = 38) served as controls. Solid phase gastric emptying was assessed by radionuclide scintigraphy. OCTT was determined by measuring exhaled breath hydrogen upon administration of lactulose. RESULTS: The two groups were similar with respect to age, sex, race, and history of smoking. Gastric emptying (t1/2) was 64.96 +/- 3.61 min in the HP-negative and 61.0 +/- 6.59 in the HP-positive group (p = NS). The OCTT was 130.9 +/- 17.26 minutes in the HP-negative and 84.28 +/- 11.07 in the HP-positive group (p = 0.03). There was no difference in the prevalence of nonhydrogen producers between the two groups. There was no correlation between gastric emptying and OCTT (p > 0.05). CONCLUSIONS: OCTT is faster among HP-positive patients with NUD than among HP-negative patients. However, gastric emptying is similar in the two groups. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/7942670/Alterations_in_upper_gastrointestinal_motility_in_Helicobacter_pylori_positive_nonulcer_dyspepsia_ L2 - http://www.diseaseinfosearch.org/result/2394 DB - PRIME DP - Unbound Medicine ER -