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Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation.
Am J Gastroenterol. 1994 Nov; 89(11):1998-2002.AJ

Abstract

OBJECTIVES

The reported prevalence of enteric pathogens, especially microsporidiosis, in HIV infection varies greatly. In this study, the prevalence rates for microsporidiosis and other enteric pathogens in HIV-infected individuals referred for gastrointestinal symptoms were compared.

METHODS

This prospective study included 250 HIV-infected individuals (179 with AIDS) who were referred for GI evaluation (diarrhea in 194). The prevalence rates of symptomatic intestinal disease due to microsporidiosis and other intestinal pathogens were determined by clinical evaluation, and their epidemiological, clinical, and immunological characteristics were compared.

RESULTS

Enteric pathogens were identified in 83% of 141 AIDS patients with diarrhea, 2% of 53 AIDS patients without diarrhea, and 3% of 56 non-AIDS patients. Microsporidia was the most common pathogen found (39% of AIDS patients with diarrhea). Two or more coexisting infections were found in 28% of AIDS patients with diarrhea. The prevalence rates for coexisting infections were similar to those predicted from the individual prevalence rates, with the exception of cryptosporidiosis and microsporidiosis, which were lower than predicted. Patients with microsporidiosis had severely depressed CD4 lymphocyte counts in peripheral blood. All patients with microsporidiosis, except one, had diarrhea, and D xylose malabsorption was universal in patients with microsporidiosis.

CONCLUSION

Microsporidiosis is a common cause of chronic diarrhea, malabsorption, and weight loss in AIDS patients.

Authors+Show Affiliations

Department of Medicine, St. Luke's-Roosevelt Hospital Center, Columbia University, New York.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7942725

Citation

Kotler, D P., and J M. Orenstein. "Prevalence of Intestinal Microsporidiosis in HIV-infected Individuals Referred for Gastroenterological Evaluation." The American Journal of Gastroenterology, vol. 89, no. 11, 1994, pp. 1998-2002.
Kotler DP, Orenstein JM. Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation. Am J Gastroenterol. 1994;89(11):1998-2002.
Kotler, D. P., & Orenstein, J. M. (1994). Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation. The American Journal of Gastroenterology, 89(11), 1998-2002.
Kotler DP, Orenstein JM. Prevalence of Intestinal Microsporidiosis in HIV-infected Individuals Referred for Gastroenterological Evaluation. Am J Gastroenterol. 1994;89(11):1998-2002. PubMed PMID: 7942725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation. AU - Kotler,D P, AU - Orenstein,J M, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 1998 EP - 2002 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 89 IS - 11 N2 - OBJECTIVES: The reported prevalence of enteric pathogens, especially microsporidiosis, in HIV infection varies greatly. In this study, the prevalence rates for microsporidiosis and other enteric pathogens in HIV-infected individuals referred for gastrointestinal symptoms were compared. METHODS: This prospective study included 250 HIV-infected individuals (179 with AIDS) who were referred for GI evaluation (diarrhea in 194). The prevalence rates of symptomatic intestinal disease due to microsporidiosis and other intestinal pathogens were determined by clinical evaluation, and their epidemiological, clinical, and immunological characteristics were compared. RESULTS: Enteric pathogens were identified in 83% of 141 AIDS patients with diarrhea, 2% of 53 AIDS patients without diarrhea, and 3% of 56 non-AIDS patients. Microsporidia was the most common pathogen found (39% of AIDS patients with diarrhea). Two or more coexisting infections were found in 28% of AIDS patients with diarrhea. The prevalence rates for coexisting infections were similar to those predicted from the individual prevalence rates, with the exception of cryptosporidiosis and microsporidiosis, which were lower than predicted. Patients with microsporidiosis had severely depressed CD4 lymphocyte counts in peripheral blood. All patients with microsporidiosis, except one, had diarrhea, and D xylose malabsorption was universal in patients with microsporidiosis. CONCLUSION: Microsporidiosis is a common cause of chronic diarrhea, malabsorption, and weight loss in AIDS patients. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/7942725/Prevalence_of_intestinal_microsporidiosis_in_HIV_infected_individuals_referred_for_gastroenterological_evaluation_ L2 - http://www.diseaseinfosearch.org/result/4799 DB - PRIME DP - Unbound Medicine ER -