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Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy?
J Paediatr Child Health 1994; 30(4):316-8JP

Abstract

To test the hypothesis that cow's milk protein intolerance (CMPI) might cause or contribute to gastro-oesophageal reflux (GOR), 10 of 14 infants with abnormal GOR on prolonged oesophageal pH monitoring who had failed to respond to conventional antireflux therapy were placed on a hypo-allergenic diet for 1 month. In no child was there significant improvement in pH monitoring indices, and only two showed any symptomatic improvement. Therefore, in these children, CMPI did not appear to contribute to GOR. It is probable that CMPI is rare as a cause of passive GOR, although our results do not exclude CMPI as a cause of active vomiting.

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  • Publisher Full Text

    • Authors+Show Affiliations

    McLain BI
    Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Australia.
    Cameron DJ
    No affiliation info available
    Barnes GL
    No affiliation info available

    MeSH

    AnimalsEsophagoscopyFemaleGastroesophageal RefluxHumansHydrogen-Ion ConcentrationInfantInfant Nutritional Physiological PhenomenaMaleMilkMilk Proteins

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    7946542

    Citation

    McLain, B I., et al. "Is Cow's Milk Protein Intolerance a Cause of Gastro-oesophageal Reflux in Infancy?" Journal of Paediatrics and Child Health, vol. 30, no. 4, 1994, pp. 316-8.
    McLain BI, Cameron DJ, Barnes GL. Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy? J Paediatr Child Health. 1994;30(4):316-8.
    McLain, B. I., Cameron, D. J., & Barnes, G. L. (1994). Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy? Journal of Paediatrics and Child Health, 30(4), pp. 316-8.
    McLain BI, Cameron DJ, Barnes GL. Is Cow's Milk Protein Intolerance a Cause of Gastro-oesophageal Reflux in Infancy. J Paediatr Child Health. 1994;30(4):316-8. PubMed PMID: 7946542.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy? AU - McLain,B I, AU - Cameron,D J, AU - Barnes,G L, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 316 EP - 8 JF - Journal of paediatrics and child health JO - J Paediatr Child Health VL - 30 IS - 4 N2 - To test the hypothesis that cow's milk protein intolerance (CMPI) might cause or contribute to gastro-oesophageal reflux (GOR), 10 of 14 infants with abnormal GOR on prolonged oesophageal pH monitoring who had failed to respond to conventional antireflux therapy were placed on a hypo-allergenic diet for 1 month. In no child was there significant improvement in pH monitoring indices, and only two showed any symptomatic improvement. Therefore, in these children, CMPI did not appear to contribute to GOR. It is probable that CMPI is rare as a cause of passive GOR, although our results do not exclude CMPI as a cause of active vomiting. SN - 1034-4810 UR - https://www.unboundmedicine.com/medline/citation/7946542/Is_cow's_milk_protein_intolerance_a_cause_of_gastro_oesophageal_reflux_in_infancy L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1034-4810&date=1994&volume=30&issue=4&spage=316 DB - PRIME DP - Unbound Medicine ER -