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Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy?
J Paediatr Child Health. 1994 Aug; 30(4):316-8.JP

Abstract

To test the hypothesis that cow's milk protein intolerance (CMPI) might cause or contribute to gastro-oesophageal reflux (GOR), 10 of 14 infants with abnormal GOR on prolonged oesophageal pH monitoring who had failed to respond to conventional antireflux therapy were placed on a hypo-allergenic diet for 1 month. In no child was there significant improvement in pH monitoring indices, and only two showed any symptomatic improvement. Therefore, in these children, CMPI did not appear to contribute to GOR. It is probable that CMPI is rare as a cause of passive GOR, although our results do not exclude CMPI as a cause of active vomiting.

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Authors+Show Affiliations

McLain BI
Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Australia.
Cameron DJ
No affiliation info available
Barnes GL
No affiliation info available

MeSH

AnimalsEsophagoscopyFemaleGastroesophageal RefluxHumansHydrogen-Ion ConcentrationInfantInfant Nutritional Physiological PhenomenaMaleMilkMilk Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7946542

Citation

McLain, B I., et al. "Is Cow's Milk Protein Intolerance a Cause of Gastro-oesophageal Reflux in Infancy?" Journal of Paediatrics and Child Health, vol. 30, no. 4, 1994, pp. 316-8.
McLain BI, Cameron DJ, Barnes GL. Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy? J Paediatr Child Health. 1994;30(4):316-8.
McLain, B. I., Cameron, D. J., & Barnes, G. L. (1994). Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy? Journal of Paediatrics and Child Health, 30(4), 316-8.
McLain BI, Cameron DJ, Barnes GL. Is Cow's Milk Protein Intolerance a Cause of Gastro-oesophageal Reflux in Infancy. J Paediatr Child Health. 1994;30(4):316-8. PubMed PMID: 7946542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy? AU - McLain,B I, AU - Cameron,D J, AU - Barnes,G L, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 316 EP - 8 JF - Journal of paediatrics and child health JO - J Paediatr Child Health VL - 30 IS - 4 N2 - To test the hypothesis that cow's milk protein intolerance (CMPI) might cause or contribute to gastro-oesophageal reflux (GOR), 10 of 14 infants with abnormal GOR on prolonged oesophageal pH monitoring who had failed to respond to conventional antireflux therapy were placed on a hypo-allergenic diet for 1 month. In no child was there significant improvement in pH monitoring indices, and only two showed any symptomatic improvement. Therefore, in these children, CMPI did not appear to contribute to GOR. It is probable that CMPI is rare as a cause of passive GOR, although our results do not exclude CMPI as a cause of active vomiting. SN - 1034-4810 UR - https://www.unboundmedicine.com/medline/citation/7946542/Is_cow's_milk_protein_intolerance_a_cause_of_gastro_oesophageal_reflux_in_infancy L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1034-4810&date=1994&volume=30&issue=4&spage=316 DB - PRIME DP - Unbound Medicine ER -