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Central hypothyroidism--various types of TSH responses to TRH stimulation.
Endocr Regul. 1994 Mar; 28(1):35-40.ER

Abstract

Thyrotropin (TSH) levels in serum before and 20 and 60 min after the administration of 0.2 mg TRH i.v. as well as thyroid hormone (T3, T4) levels were studied in 39 patients with organic diencephalo-pituitary lesions and 27 healthy subjects. All participants gave their informed consent with the study. By the type of TSH response to TRH stimulation all patients were divided into 4 groups: 1. Normal response (n = 10): basal TSH 2.31 +/- 1.51, peak TSH 20 min after TRH 12.17 +/- 6.53, TSH 60 min after TRH 8.43 +/- 4.65 microU/ml; T3 2.02 +/- 0.48 and T4 95.9 +/- 27.73 nmol/l; 2. Blunted or absent TSH response (n = 8): basal TSH 0.82 +/- 0.42, peak TSH 20 min after TRH 1.51 +/- 0.66, TSH 60 min after TRH 1.35 +/- 0.51 microU/ml; T3 1.6 +/- 0.49 and T4 86.63 +/- 16.49 nmol/l; 3. Delayed ("diencephalic") TSH response (n = 16): basal TSH 2.69 +/- 1.27, peak TSH 20 min after TRH 7.96 +/- 3.35, TSH 60 min after TRH 10.0 +/- 3.97 microU/ml; T3 1.30 +/- 0.63 and T4 65.85 +/- 21.13 nmol/l; 4. Higher basal or stimulated TSH (n = 10): basal TSH > 10 mU/ml or stimulated values above 25 mU/ml. Mean T3 and T4 values in patients with normal or blunted TSH response did not differ significantly from the controls. Mean T3 and T4 in the group with delayed TSH response were significantly lower (P < 0.01). High TSH and low T3 and T4 levels were found in the patient with large meningioma sellae.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

2nd Department of Internal Medicine, P. J. Safárik University, Faculty of Medicine, Kosice, Slovak Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7949012

Citation

Trejbal, D, et al. "Central Hypothyroidism--various Types of TSH Responses to TRH Stimulation." Endocrine Regulations, vol. 28, no. 1, 1994, pp. 35-40.
Trejbal D, Sulla I, Trejbalová L, et al. Central hypothyroidism--various types of TSH responses to TRH stimulation. Endocr Regul. 1994;28(1):35-40.
Trejbal, D., Sulla, I., Trejbalová, L., Lazúrová, I., Schwartz, P., & Machánová, Y. (1994). Central hypothyroidism--various types of TSH responses to TRH stimulation. Endocrine Regulations, 28(1), 35-40.
Trejbal D, et al. Central Hypothyroidism--various Types of TSH Responses to TRH Stimulation. Endocr Regul. 1994;28(1):35-40. PubMed PMID: 7949012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central hypothyroidism--various types of TSH responses to TRH stimulation. AU - Trejbal,D, AU - Sulla,I, AU - Trejbalová,L, AU - Lazúrová,I, AU - Schwartz,P, AU - Machánová,Y, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 35 EP - 40 JF - Endocrine regulations JO - Endocr Regul VL - 28 IS - 1 N2 - Thyrotropin (TSH) levels in serum before and 20 and 60 min after the administration of 0.2 mg TRH i.v. as well as thyroid hormone (T3, T4) levels were studied in 39 patients with organic diencephalo-pituitary lesions and 27 healthy subjects. All participants gave their informed consent with the study. By the type of TSH response to TRH stimulation all patients were divided into 4 groups: 1. Normal response (n = 10): basal TSH 2.31 +/- 1.51, peak TSH 20 min after TRH 12.17 +/- 6.53, TSH 60 min after TRH 8.43 +/- 4.65 microU/ml; T3 2.02 +/- 0.48 and T4 95.9 +/- 27.73 nmol/l; 2. Blunted or absent TSH response (n = 8): basal TSH 0.82 +/- 0.42, peak TSH 20 min after TRH 1.51 +/- 0.66, TSH 60 min after TRH 1.35 +/- 0.51 microU/ml; T3 1.6 +/- 0.49 and T4 86.63 +/- 16.49 nmol/l; 3. Delayed ("diencephalic") TSH response (n = 16): basal TSH 2.69 +/- 1.27, peak TSH 20 min after TRH 7.96 +/- 3.35, TSH 60 min after TRH 10.0 +/- 3.97 microU/ml; T3 1.30 +/- 0.63 and T4 65.85 +/- 21.13 nmol/l; 4. Higher basal or stimulated TSH (n = 10): basal TSH > 10 mU/ml or stimulated values above 25 mU/ml. Mean T3 and T4 values in patients with normal or blunted TSH response did not differ significantly from the controls. Mean T3 and T4 in the group with delayed TSH response were significantly lower (P < 0.01). High TSH and low T3 and T4 levels were found in the patient with large meningioma sellae.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1210-0668 UR - https://www.unboundmedicine.com/medline/citation/7949012/Central_hypothyroidism__various_types_of_TSH_responses_to_TRH_stimulation_ L2 - https://medlineplus.gov/hypothyroidism.html DB - PRIME DP - Unbound Medicine ER -