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IgA endomysium antibody: a valuable tool in the screening of coeliac disease but not its follow-up.
Ital J Gastroenterol 1994 Jul-Aug; 26(6):279-82IJ

Abstract

The IgA antiendomysium antibody was found in 99 of 100 consecutive patients with adult untreated coeliac disease, whereas IgA and/or IgG antigliadin antibodies were found in 92 of the same patients. Twenty-nine of them, presenting with minimal, transient or apparently unrelated symptoms (subclinical presentation), were antiendomysium antibody positive, whereas antigliadin antibodies were present in 26. In 33 of them, we also investigated the relationship between circulating antiendomysium antibody and the persistence of jejunal lesions after the institution of a gluten-free diet. Although 24 treated coeliac patients turned out to be antiendomysium antibody negative, in 17 of them jejunal lesions persisted. The present study shows that IgA antiendomysium antibody is a highly sensitive and specific marker for both subclinical and classical coeliac disease, but that it is not a reliable test in the follow up of coeliac patients.

Authors+Show Affiliations

Dipartimento di Medicina Interna, Università dell'Aquila, Roma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7949263

Citation

Valentini, R A., et al. "IgA Endomysium Antibody: a Valuable Tool in the Screening of Coeliac Disease but Not Its Follow-up." The Italian Journal of Gastroenterology, vol. 26, no. 6, 1994, pp. 279-82.
Valentini RA, Andreani ML, Corazza GR, et al. IgA endomysium antibody: a valuable tool in the screening of coeliac disease but not its follow-up. Ital J Gastroenterol. 1994;26(6):279-82.
Valentini, R. A., Andreani, M. L., Corazza, G. R., & Gasbarrini, G. (1994). IgA endomysium antibody: a valuable tool in the screening of coeliac disease but not its follow-up. The Italian Journal of Gastroenterology, 26(6), pp. 279-82.
Valentini RA, et al. IgA Endomysium Antibody: a Valuable Tool in the Screening of Coeliac Disease but Not Its Follow-up. Ital J Gastroenterol. 1994;26(6):279-82. PubMed PMID: 7949263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA endomysium antibody: a valuable tool in the screening of coeliac disease but not its follow-up. AU - Valentini,R A, AU - Andreani,M L, AU - Corazza,G R, AU - Gasbarrini,G, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 279 EP - 82 JF - The Italian journal of gastroenterology JO - Ital J Gastroenterol VL - 26 IS - 6 N2 - The IgA antiendomysium antibody was found in 99 of 100 consecutive patients with adult untreated coeliac disease, whereas IgA and/or IgG antigliadin antibodies were found in 92 of the same patients. Twenty-nine of them, presenting with minimal, transient or apparently unrelated symptoms (subclinical presentation), were antiendomysium antibody positive, whereas antigliadin antibodies were present in 26. In 33 of them, we also investigated the relationship between circulating antiendomysium antibody and the persistence of jejunal lesions after the institution of a gluten-free diet. Although 24 treated coeliac patients turned out to be antiendomysium antibody negative, in 17 of them jejunal lesions persisted. The present study shows that IgA antiendomysium antibody is a highly sensitive and specific marker for both subclinical and classical coeliac disease, but that it is not a reliable test in the follow up of coeliac patients. SN - 0392-0623 UR - https://www.unboundmedicine.com/medline/citation/7949263/IgA_endomysium_antibody:_a_valuable_tool_in_the_screening_of_coeliac_disease_but_not_its_follow_up_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -