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Oral cooling (cryotherapy), an effective treatment for the prevention of 5-fluorouracil-induced stomatitis.

Abstract

Recently, a randomised study demonstrated the utility of oral cooling (cryotherapy) in the prevention of 5-fluorouracil (5FU)-induced stomatitis. In order to verify these results a confirmatory study, using identical treatment regimen, was initiated. 84 patients treated with a 5-FU-containing regimen were randomised to a control arm or to receive oral cryotherapy. End point evaluation was obtained by a global assessment of the physician's judgement and patients' description of mucositis severity graded 0-4. Mucositis was significantly reduced by cryotherapy considering both the first cycle of therapy (the mean toxicity score for cryotherapy was 0.59 and it was 1.1 for the control group, P < or = 0.05) and all the chemotherapeutic courses (the mean toxicity score for cryotherapy was 0.36 when it was 0.69 for the control group, P < or = 0.05). In conclusion, the present study confirms that cryotherapy can decrease 5FU-induced stomatitis and should be recommended for patients receiving bolus 5FU-containing regimens.

Authors+Show Affiliations

,

Servizio di Oncologia, Ospedali Riuniti, Pesaro, Italy.

, ,

Source

MeSH

Adult
Aged
Cryotherapy
Female
Fluorouracil
Humans
Male
Middle Aged
Smoking
Stomatitis

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7950836

Citation

Cascinu, S, et al. "Oral Cooling (cryotherapy), an Effective Treatment for the Prevention of 5-fluorouracil-induced Stomatitis." European Journal of Cancer. Part B, Oral Oncology, vol. 30B, no. 4, 1994, pp. 234-6.
Cascinu S, Fedeli A, Fedeli SL, et al. Oral cooling (cryotherapy), an effective treatment for the prevention of 5-fluorouracil-induced stomatitis. Eur J Cancer, B, Oral Oncol. 1994;30B(4):234-6.
Cascinu, S., Fedeli, A., Fedeli, S. L., & Catalano, G. (1994). Oral cooling (cryotherapy), an effective treatment for the prevention of 5-fluorouracil-induced stomatitis. European Journal of Cancer. Part B, Oral Oncology, 30B(4), pp. 234-6.
Cascinu S, et al. Oral Cooling (cryotherapy), an Effective Treatment for the Prevention of 5-fluorouracil-induced Stomatitis. Eur J Cancer, B, Oral Oncol. 1994;30B(4):234-6. PubMed PMID: 7950836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral cooling (cryotherapy), an effective treatment for the prevention of 5-fluorouracil-induced stomatitis. AU - Cascinu,S, AU - Fedeli,A, AU - Fedeli,S L, AU - Catalano,G, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 234 EP - 6 JF - European journal of cancer. Part B, Oral oncology JO - Eur. J. Cancer, B, Oral Oncol. VL - 30B IS - 4 N2 - Recently, a randomised study demonstrated the utility of oral cooling (cryotherapy) in the prevention of 5-fluorouracil (5FU)-induced stomatitis. In order to verify these results a confirmatory study, using identical treatment regimen, was initiated. 84 patients treated with a 5-FU-containing regimen were randomised to a control arm or to receive oral cryotherapy. End point evaluation was obtained by a global assessment of the physician's judgement and patients' description of mucositis severity graded 0-4. Mucositis was significantly reduced by cryotherapy considering both the first cycle of therapy (the mean toxicity score for cryotherapy was 0.59 and it was 1.1 for the control group, P < or = 0.05) and all the chemotherapeutic courses (the mean toxicity score for cryotherapy was 0.36 when it was 0.69 for the control group, P < or = 0.05). In conclusion, the present study confirms that cryotherapy can decrease 5FU-induced stomatitis and should be recommended for patients receiving bolus 5FU-containing regimens. SN - 0964-1955 UR - https://www.unboundmedicine.com/medline/citation/7950836/full_citation DB - PRIME DP - Unbound Medicine ER -