Tags

Type your tag names separated by a space and hit enter

A case of toxic megacolon in ulcerative colitis associated with cytomegalovirus infection.
J Gastroenterol. 1994 Aug; 29(4):501-5.JG

Abstract

Cytomegalovirus (CMV) infection, which has been shown to complicate the course of ulcerative colitis (UC), has been implicated as a possible etiologic factor in the exacerbation of UC, especially in toxic megacolon. However, CMV infection in patients with UC accompanied by toxic megacolon has rarely been reported. Here we report a case of CMV infection of the colon accompanied by toxic megacolon occurring in UC. A 38-year-old woman had been treated with intravenous hydrocortisone, rectal steroid, and central venous alimentation for 6 weeks under the diagnosis of UC. She was transferred to Akita University Hospital because of increasing bloody diarrhea and abdominal pain. Toxic megacolon was identified by examinations on admission, and she underwent a total colectomy. Examination of the surgical specimen showed severe inflammation of the colon. Microscopically, cytomegalic inclusions were observed in and around the endothelial cells in the inflamed submucosal layer. It can be assumed that CMV infection was a secondary, opportunistic invader superimposed on UC, and that it played an important role in altering the clinical course of the patient.

Authors+Show Affiliations

First Department of Surgery, Akita University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7951862

Citation

Kotanagi, H, et al. "A Case of Toxic Megacolon in Ulcerative Colitis Associated With Cytomegalovirus Infection." Journal of Gastroenterology, vol. 29, no. 4, 1994, pp. 501-5.
Kotanagi H, Fukuoka T, Shibata Y, et al. A case of toxic megacolon in ulcerative colitis associated with cytomegalovirus infection. J Gastroenterol. 1994;29(4):501-5.
Kotanagi, H., Fukuoka, T., Shibata, Y., Yoshioka, T., Aizawa, O., Saito, Y., Koyama, K., Otaka, M., Chiba, M., & Saito, M. (1994). A case of toxic megacolon in ulcerative colitis associated with cytomegalovirus infection. Journal of Gastroenterology, 29(4), 501-5.
Kotanagi H, et al. A Case of Toxic Megacolon in Ulcerative Colitis Associated With Cytomegalovirus Infection. J Gastroenterol. 1994;29(4):501-5. PubMed PMID: 7951862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of toxic megacolon in ulcerative colitis associated with cytomegalovirus infection. AU - Kotanagi,H, AU - Fukuoka,T, AU - Shibata,Y, AU - Yoshioka,T, AU - Aizawa,O, AU - Saito,Y, AU - Koyama,K, AU - Otaka,M, AU - Chiba,M, AU - Saito,M, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 501 EP - 5 JF - Journal of gastroenterology JO - J Gastroenterol VL - 29 IS - 4 N2 - Cytomegalovirus (CMV) infection, which has been shown to complicate the course of ulcerative colitis (UC), has been implicated as a possible etiologic factor in the exacerbation of UC, especially in toxic megacolon. However, CMV infection in patients with UC accompanied by toxic megacolon has rarely been reported. Here we report a case of CMV infection of the colon accompanied by toxic megacolon occurring in UC. A 38-year-old woman had been treated with intravenous hydrocortisone, rectal steroid, and central venous alimentation for 6 weeks under the diagnosis of UC. She was transferred to Akita University Hospital because of increasing bloody diarrhea and abdominal pain. Toxic megacolon was identified by examinations on admission, and she underwent a total colectomy. Examination of the surgical specimen showed severe inflammation of the colon. Microscopically, cytomegalic inclusions were observed in and around the endothelial cells in the inflamed submucosal layer. It can be assumed that CMV infection was a secondary, opportunistic invader superimposed on UC, and that it played an important role in altering the clinical course of the patient. SN - 0944-1174 UR - https://www.unboundmedicine.com/medline/citation/7951862/A_case_of_toxic_megacolon_in_ulcerative_colitis_associated_with_cytomegalovirus_infection_ L2 - http://www.diseaseinfosearch.org/result/7285 DB - PRIME DP - Unbound Medicine ER -