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Effect of inhaled bradykinin on indices of airway responsiveness in asthmatic subjects.
Eur Respir J. 1994 Aug; 7(8):1490-6.ER

Abstract

Asthma is characterized by airway hyperresponsiveness, a physiopathological abnormality which may result from the complex interplay between inflammatory cells and proinflammatory mediators. Although kinins are thought to play a role in the pathogenesis of bronchial asthma, it is not known whether bradykinin is able to induce airway hyperresponsiveness. We have, therefore, investigated the effect of inhaled bradykinin on the changes in airway calibre and in airway hyperresponsiveness to histamine, in a double-blind, randomized study of nine asthmatic subjects. Subjects were studied on two study periods, separated by at least 15 days. On the first day of each study period, subjects inhaled either a single dose of bradykinin or methacholine (placebo) with changes in airway calibre being followed as forced expiratory volume in one second (FEV1) and as the maximum expiratory flow rate measured at 70% of the vital capacity below total lung capacity (TLC) from a partial forced expiratory manoeuvre (Vp30) at 3, 5, 10, 15, 30, 45 and 60 min, and then every hour for 7 h. Airway responsiveness to histamine, expressed as the provocative concentrations producing a 20% fall in FEV1 and 40% fall in Vp30 (PC20FEV1 and PC40Vp30), was measured at 3 and 7 h after inhaling the agonists, then on days 1, 3, 7 and 14. Inhalation of bradykinin caused rapid bronchoconstriction that peaked at 3-5 min. When compared to placebo, no significant difference in histamine responsiveness was seen after bradykinin in terms of changes in PC20FEV1 values.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Istituto Malattie Apparato Respiratorio, University of Catania, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7957835

Citation

Polosa, R, et al. "Effect of Inhaled Bradykinin On Indices of Airway Responsiveness in Asthmatic Subjects." The European Respiratory Journal, vol. 7, no. 8, 1994, pp. 1490-6.
Polosa R, Rajakulasingam K, Prosperini G, et al. Effect of inhaled bradykinin on indices of airway responsiveness in asthmatic subjects. Eur Respir J. 1994;7(8):1490-6.
Polosa, R., Rajakulasingam, K., Prosperini, G., Bellofiore, S., Britten, S., Milazzo, L. V., & Holgate, S. T. (1994). Effect of inhaled bradykinin on indices of airway responsiveness in asthmatic subjects. The European Respiratory Journal, 7(8), 1490-6.
Polosa R, et al. Effect of Inhaled Bradykinin On Indices of Airway Responsiveness in Asthmatic Subjects. Eur Respir J. 1994;7(8):1490-6. PubMed PMID: 7957835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of inhaled bradykinin on indices of airway responsiveness in asthmatic subjects. AU - Polosa,R, AU - Rajakulasingam,K, AU - Prosperini,G, AU - Bellofiore,S, AU - Britten,S, AU - Milazzo,L V, AU - Holgate,S T, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 1490 EP - 6 JF - The European respiratory journal JO - Eur. Respir. J. VL - 7 IS - 8 N2 - Asthma is characterized by airway hyperresponsiveness, a physiopathological abnormality which may result from the complex interplay between inflammatory cells and proinflammatory mediators. Although kinins are thought to play a role in the pathogenesis of bronchial asthma, it is not known whether bradykinin is able to induce airway hyperresponsiveness. We have, therefore, investigated the effect of inhaled bradykinin on the changes in airway calibre and in airway hyperresponsiveness to histamine, in a double-blind, randomized study of nine asthmatic subjects. Subjects were studied on two study periods, separated by at least 15 days. On the first day of each study period, subjects inhaled either a single dose of bradykinin or methacholine (placebo) with changes in airway calibre being followed as forced expiratory volume in one second (FEV1) and as the maximum expiratory flow rate measured at 70% of the vital capacity below total lung capacity (TLC) from a partial forced expiratory manoeuvre (Vp30) at 3, 5, 10, 15, 30, 45 and 60 min, and then every hour for 7 h. Airway responsiveness to histamine, expressed as the provocative concentrations producing a 20% fall in FEV1 and 40% fall in Vp30 (PC20FEV1 and PC40Vp30), was measured at 3 and 7 h after inhaling the agonists, then on days 1, 3, 7 and 14. Inhalation of bradykinin caused rapid bronchoconstriction that peaked at 3-5 min. When compared to placebo, no significant difference in histamine responsiveness was seen after bradykinin in terms of changes in PC20FEV1 values.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/7957835/Effect_of_inhaled_bradykinin_on_indices_of_airway_responsiveness_in_asthmatic_subjects_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=7957835 DB - PRIME DP - Unbound Medicine ER -