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[New alternatives in the treatment of bacterial vaginosis].
Ginecol Obstet Mex. 1994 Aug; 62:226-34.GO

Abstract

Efficiency and security clindamycin vaginal cream (2%) were compared to oral metronidazole's for the treatment of 184 women with symptomatic bacterial vaginosis in a multicentric, randomized, double-blind, controlled study. The treatment was of 7 days duration, using placebo capsules for the clindamycin group and placebo cream for the metronidazole group. Patients were observed during a follow up (4-13 and 20-43 days after completion of therapy). Global results of this treatment indicated that clindamycin vaginal cream offers a similar efficiency than oral metronidazole. Improvement or total healing was 87% for clindamycin and 79% for metronidazole, with no significant differences (p > 0.22). No relapses were observed in the clindamycin group, and 7% in the metronidazole group. The clindamycin group had a failure rate of 3% compared to 15% in the oral metronidazole group. Both drugs were well tolerated. Side effects more frequently reported were vulvovaginal irritation and cervicitis/vaginitis. The only side effect that could have been classified as serious was a generalized rash in a patient receiving metronidazole. It was concluded that clindamycin vaginal cream (2%) is an efficient and secure alternative to oral metronidazole for the treatment of bacterial vaginosis being the elective therapy for pregnant women in their first gestational trimester.

Authors+Show Affiliations

Departamento de Infectología e Inmunología, Instituto Nacional de Perinatología, México, D.F.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

spa

PubMed ID

7959144

Citation

Luis Arredondo, J, et al. "[New Alternatives in the Treatment of Bacterial Vaginosis]." Ginecologia Y Obstetricia De Mexico, vol. 62, 1994, pp. 226-34.
Luis Arredondo J, Higuera F, Narcio ML, et al. [New alternatives in the treatment of bacterial vaginosis]. Ginecol Obstet Mex. 1994;62:226-34.
Luis Arredondo, J., Higuera, F., Narcio, M. L., Casanova, G., & Beltrán, M. (1994). [New alternatives in the treatment of bacterial vaginosis]. Ginecologia Y Obstetricia De Mexico, 62, 226-34.
Luis Arredondo J, et al. [New Alternatives in the Treatment of Bacterial Vaginosis]. Ginecol Obstet Mex. 1994;62:226-34. PubMed PMID: 7959144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [New alternatives in the treatment of bacterial vaginosis]. AU - Luis Arredondo,J, AU - Higuera,F, AU - Narcio,M L, AU - Casanova,G, AU - Beltrán,M, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 226 EP - 34 JF - Ginecologia y obstetricia de Mexico JO - Ginecol Obstet Mex VL - 62 N2 - Efficiency and security clindamycin vaginal cream (2%) were compared to oral metronidazole's for the treatment of 184 women with symptomatic bacterial vaginosis in a multicentric, randomized, double-blind, controlled study. The treatment was of 7 days duration, using placebo capsules for the clindamycin group and placebo cream for the metronidazole group. Patients were observed during a follow up (4-13 and 20-43 days after completion of therapy). Global results of this treatment indicated that clindamycin vaginal cream offers a similar efficiency than oral metronidazole. Improvement or total healing was 87% for clindamycin and 79% for metronidazole, with no significant differences (p > 0.22). No relapses were observed in the clindamycin group, and 7% in the metronidazole group. The clindamycin group had a failure rate of 3% compared to 15% in the oral metronidazole group. Both drugs were well tolerated. Side effects more frequently reported were vulvovaginal irritation and cervicitis/vaginitis. The only side effect that could have been classified as serious was a generalized rash in a patient receiving metronidazole. It was concluded that clindamycin vaginal cream (2%) is an efficient and secure alternative to oral metronidazole for the treatment of bacterial vaginosis being the elective therapy for pregnant women in their first gestational trimester. SN - 0300-9041 UR - https://www.unboundmedicine.com/medline/citation/7959144/[New_alternatives_in_the_treatment_of_bacterial_vaginosis]_ DB - PRIME DP - Unbound Medicine ER -